Genes to remember: imaging genetics of hippocampus-based memory functions

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MARC

Kauppi, Karolina,1985-Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB) (author)

Genes to remember : imaging genetics of hippocampus-based memory functions

BookEnglish2013

Publisher, publication year, extent ...

Umeå :Umeå Universitet,2013
84 s.
electronicrdacarrier

Numbers

LIBRIS-ID:oai:DiVA.org:umu-71141
ISBN:9789174595987
ISBN:9789174595970
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-71141URI

Supplementary language notes

Language:English
Summary in:English

Part of subdatabase

SwePubSwePub

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Subject category:vet swepub-contenttype
Subject category:dok swepub-publicationtype

Series

Umeå University medical dissertations,0346-6612 ;1580

Notes

In the field of imaging genetics, brain function and structure are used as intermediate phenotypes between genes and cognition/diseases to validate and extend findings from behavioral genetics. In this thesis, three of the strongest candidate genes for episodic memory, KIBRA, BDNF, and APOE, were examined in relation to memory performance and hippocampal/parahippocampal fMRI blood-oxygen level-dependent (BOLD) signal. A common T allele in the KIBRA gene was previously associated with superior memory, and increased hippocampal activation was observed in noncarriers of the T allele which was interpreted as reflecting compensatory recruitment. The results from the first study revealed that both memory performance and hippocampal activation at retrieval was higher in T allele carriers (study I). The BDNF 66Met and APOE ε4 alleles have previously been associated with poorer memory performance, but their relation to brain activation has been inconsistent with reports of both increased and decreased regional brain activation relative to noncarriers. Here, decreased hippocampal/parahippocampal activation was observed in carriers of BDNF 66Met (study II) as well as APOE ε4 (study III) during memory encoding. In addition, there was an additive gene-gene effect of APOE and BDNF on hippocampal and parahippocampal activation (study III). Collectively, the results from these studies on KIBRA, BDNF, and APOE converge on higher medial temporal lobe activation for carriers of a high-memory associated allele, relative to carriers of a low-memory associated allele. In addition, the observed additive effect of APOE and BDNF demonstrate that a larger amount of variance in BOLD signal change can be explained by considering the combined effect of more than one genetic polymorphism. These imaging genetics findings support and extend previous knowledge from behavioral genetics on the role of these memory-related genes.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Neurovetenskaper hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Neurosciences hsv//eng
Imaging genetics
fMRI
Episodic memory
SNP
KIBRA
BDNF
APOE
Hippocampus
Parahippocampus

Added entries (persons, corporate bodies, meetings, titles ...)

Nyberg, Lars,ProfessorUmeå universitet,Institutionen för integrativ medicinsk biologi (IMB),Institutionen för strålningsvetenskaper(Swepub:umu)lany0001 (thesis advisor)
Persson, Jonas,DocentStockholm Universitet (thesis advisor)
Fernández, Guillén,ProfessorDonders Centre for Cognitive Neuroimaging, Nijmegen, Nederländerna (opponent)
Umeå universitetInstitutionen för integrativ medicinsk biologi (IMB) (creator_code:org_t)

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