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Comparison of Body ...
Comparison of Body Surface Area versus Weight-Based Growth Hormone Dosing for Girls with Turner Syndrome
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Schrier, Lenneke (author)
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de Kam, Marieke L. (author)
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McKinnon, Rachel (author)
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Bakri, Amalina Che (author)
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Oostdijk, Wilma (author)
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Sas, Theo C. J. (author)
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Menke, Leonie A. (author)
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Otten, Barto J. (author)
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Keizer-Schrama, Sabine M. P. F. de Muinck (author)
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- Kriström, Berit (author)
- Umeå universitet,Pediatrik
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- Ankarberg-Lindgren, Carina, 1963 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics
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Burggraaf, Jacobus (author)
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- Albertsson-Wikland, Kerstin, 1947 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics
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Wit, Jan M. (author)
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(creator_code:org_t)
- 2014-04-23
- 2014
- English.
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In: Hormone Research in Paediatrics. - : S. Karger AG. - 1663-2818 .- 1663-2826. ; 81:5, s. 319-330
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https://www.karger.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Background/Aims: Growth Hormone (GH) dosage in childhood is adjusted for body size, but there is no consensus whether body weight (BW) or body surface area (BSA) should be used. We aimed at comparing the biological effect and cost-effectiveness of GH treatment dosed per m(2) BSA in comparison with dosing per kg BW in girls with Turner syndrome (TS). Methods: Serum IGF-I, GH dose, and adult height gain (AHG) from girls participating in two Dutch and five Swedish studies on the efficacy of GH were analyzed, and the cumulative GH dose and costs were calculated for both dose adjustment methods. Additional medication included estrogens (if no spontaneous puberty occurred) and oxandrolone in some studies. Results: At each GH dose, the serum IGF-I standard deviation score remained stable over time after an initial increase after the start of treatment. On a high dose (at 1 m(2) equivalent to 0.056-0.067 mg/kg/day), AHG was at least equal on GH dosed per m(2) BSA compared with dosing per kg BW. The cumulative dose and cost were significantly lower if the GH dose was adjusted for m(2) BSA. Conclusion: Dosing GH per m(2) BSA is at least as efficacious as dosing per kg BW, and is more cost-effective. (C) 2014 S. Karger AG, Basel
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Keyword
- Turner syndrome
- Growth hormone therapy
- Body surface area
- Body weight
- Cost-effectiveness
- Adult height
- Turner syndrome; Growth hormone therapy; Body surface area; Body weight; Cost-effectiveness; Adult height
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Schrier, Lenneke
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de Kam, Marieke ...
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McKinnon, Rachel
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Bakri, Amalina C ...
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Oostdijk, Wilma
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Sas, Theo C. J.
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show more...
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Menke, Leonie A.
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Otten, Barto J.
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Keizer-Schrama, ...
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Kriström, Berit
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Ankarberg-Lindgr ...
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Burggraaf, Jacob ...
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Albertsson-Wikla ...
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Wit, Jan M.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Pediatrics
- Articles in the publication
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Hormone Research ...
- By the university
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Umeå University
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University of Gothenburg