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Sökning: onr:"swepub:oai:DiVA.org:umu-91501" > Association of CRP ...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005256naa a2200901 4500
001oai:DiVA.org:umu-91501
003SwePub
008140807s2015 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:130400993
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-915012 URI
0247 a https://doi.org/10.1002/ijc.290862 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1304009932 URI
040 a (SwePub)umud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Nimptsch, Katharina4 aut
2451 0a Association of CRP genetic variants with blood concentrations of C-reactive protein and colorectal cancer risk.
264 c 2014-07-28
264 1b Wiley,c 2015
338 a print2 rdacarrier
520 a High blood concentrations of C-reactive protein (CRP) have been associated with elevated risk of colorectal cancer in several prospective studies including the European Prospective Investigation into Cancer and Nutrition (EPIC), but it is unknown whether these observations reflect a causal relationship. We aimed to investigate whether CRP genetic variants associated with lifelong higher CRP concentrations translate into higher colorectal cancer risk. We conducted a prospective nested case-control study within EPIC including 727 cases diagnosed between 1992 and 2003 and 727 matched controls selected according to an incidence-density sampling protocol. Baseline CRP concentrations were measured in plasma samples by a high sensitivity assay. Tagging single nucleotide polymorphisms (SNPs) in the CRP gene (rs1205, rs1800947, rs1130864, rs2808630, rs3093077) were identified via HapMap. The causal effect of CRP on colorectal cancer risk was examined in a Mendelian Randomization approach utilizing multiple CRP genetic variants as instrumental variables. The SNPs rs1205, rs1800947, rs1130864 and rs3093077 were significantly associated with CRP concentrations and were incorporated in a CRP allele score which was associated with 13% higher CRP concentrations per allele count (95% confidence interval 8-19%). Using the CRP-score as instrumental variable, genetically twofold higher CRP concentrations were associated with higher risk of colorectal cancer (odds ratio 1.74, 95% confidence interval 1.06-2.85). Similar observations were made using alternative definitions of instrumental variables. Our findings give support to the hypothesis that elevated circulating CRP may play a direct role in the etiology of colorectal cancer.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653 a C-reactive protein
653 a CRP genetic variants
653 a colorectal cancer
653 a Oncology
653 a onkologi
7001 a Aleksandrova, Krasimira4 aut
7001 a Boeing, Heiner4 aut
7001 a Janke, Jürgen4 aut
7001 a Lee, Young-Ae4 aut
7001 a Jenab, Mazda4 aut
7001 a Bueno-De-Mesquita, Bas H4 aut
7001 a Jansen, Eugène Hjm4 aut
7001 a Tsilidis, Konstantinos K4 aut
7001 a Trichopoulou, Antonia4 aut
7001 a Weiderpass, Elisabeteu Karolinska Institutet4 aut
7001 a Wu, Chunsen4 aut
7001 a Overvad, Kim4 aut
7001 a Tjønneland, Anne4 aut
7001 a Boutron-Ruault, Marie-Christine4 aut
7001 a Dossus, Laure4 aut
7001 a Racine, Antoine4 aut
7001 a Kaaks, Rudolf4 aut
7001 a Canzian, Federico4 aut
7001 a Lagiou, Pagona4 aut
7001 a Trichopoulos, Dimitrios4 aut
7001 a Palli, Domenico4 aut
7001 a Agnoli, Claudia4 aut
7001 a Tumino, Rosario4 aut
7001 a Vineis, Paolo4 aut
7001 a Panico, Salvatore4 aut
7001 a Johansson, Anders,d 1955-u Umeå universitet,Institutionen för odontologi,Aa-gruppen4 aut0 (Swepub:umu)anjo0002
7001 a Van Guelpen, Bethanyu Umeå universitet,Institutionen för medicinsk biovetenskap4 aut
7001 a Khaw, Kay-Tee4 aut
7001 a Wareham, Nick4 aut
7001 a Peeters, Petra H4 aut
7001 a Quirós, J Ramón4 aut
7001 a Venceslá García, Adoración4 aut
7001 a Molina-Montes, Esther4 aut
7001 a Dorronsoro, Miren4 aut
7001 a Chirlaque, María-Dolores4 aut
7001 a Barricarte Gurrea, Aurelio4 aut
7001 a Key, Timothy J4 aut
7001 a Duarte-Salles, Talita4 aut
7001 a Stepien, Magdalena4 aut
7001 a Gunter, Marc J4 aut
7001 a Riboli, Elio4 aut
7001 a Pischon, Tobias4 aut
7102 a Karolinska Institutetb Institutionen för odontologi4 org
7730 t International Journal of Cancerd : Wileyg 136:5, s. 1181-1192q 136:5<1181-1192x 0020-7136x 1097-0215
8564 u https://europepmc.org/articles/pmc6284796?pdf=render
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-91501
8564 8u https://doi.org/10.1002/ijc.29086
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:130400993

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