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Generic structures of cytotoxic liprotides : nano-sized complexes with oleic acid cores and shells of disordered proteins
- Kaspersen, Jørn D. (author)
- Pedersen, Jannik N. (author)
- Hansted, Jon G. (author)
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- Nielsen, Søren B. (author)
- Sakthivel, Srinivasan (author)
- Nemashkalova, Ekaterina L. (author)
- Permyakov, Sergei E. (author)
- Permyakov, Eugene A. (author)
- Pinto Oliveira, Cristiano Luis (author)
- Otzen, Daniel E. (author)
- Pedersen, Jan Skov (author)
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- (creator_code:org_t)
- 2014-11-17
- 2014
- English.
- In: ChemBioChem. - : Wiley-VCH Verlagsgesellschaft. - 1439-4227 .- 1439-7633. ; 15:18, s. 2693-2702
- Journal article (peer-reviewed)
Abstract
Subject headings
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- The cytotoxic complex formed between alpha-lactalbumin and oleic acid (OA) has inspired many studies on protein-fatty acid complexes, but structural insight remains sparse. After having used small-angle X-ray scattering (SAXS) to obtain structural information, we present a new, generic structural model of cytotoxic protein-oleic acid complexes, which we have termed liprotides (lipids and partially denatured proteins). Twelve liprotides formed from seven structurally unrelated proteins and prepared by different procedures all displayed core-shell structures, each with a micellar OA core and a shell consisting of flexible, partially unfolded protein, which stabilizes the OA micelle. The common structure explains similar effects exerted on cells by different liprotides and is consistent with a cargo off-loading of the OA into cell membranes.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Keyword
- lipids
- micelles
- protein folding
- protein structures
- protein-protein interactions
- BYE P
- 1947
- JOURNAL OF PHYSICAL AND COLLOID CHEMISTRY
- V51
- P18 ensson M
- 1999
- JOURNAL OF BIOLOGICAL CHEMISTRY
- V274
- P6388
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- art (subject category)
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