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Arsenic is decrease...
Arsenic is decreased in target organs during viral infection in mice
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- Benyamin, Gad (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Infektionssjukdomar
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- Lindh, Ulf (författare)
- Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi,Enheten för metallbiologisk forskning
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- Frisk, Peter (författare)
- Uppsala universitet,Enheten för metallbiologisk forskning
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- Friman, Göran (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Infektionssjukdomar
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- Ilbäck, Nils-Gunnar (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Infektionssjukdomar
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(creator_code:org_t)
- Elsevier BV, 2006
- 2006
- Engelska.
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Ingår i: Journal of Trace Elements in Medicine and Biology. - : Elsevier BV. - 0946-672X .- 1878-3252. ; 20:2, s. 121-126
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Arsenic (As), a potentially toxic trace element, has been shown to influence viral replication and resistance to microbial infection. However, the impact of infection on the normal As status in target organs involved in the disease process has not been studied to date. In the present study, As was measured through inductively coupled plasma mass spectrometry in the plasma, liver, spleen, kidney, heart, pancreas and brain at days 1 and 3 of coxsackievirus B3 infection in female Balb/c mice. The severity of the infection was assessed from clinical signs of disease. The infection changed plasma As in a biphasic pattern with a small increase (n.s.) at day 1 that turned into a decreasing trend (13%, p<0.05) by day 3. In the liver, spleen, heart, pancreas and kidney As was unchanged at day 1 but, at day 3, it had decreased by 71% (p<0.01), 64% (p<0.01), 55% (p<0.01), 63% (p<0.01) and 73% (p<0.01), respectively. In the brain, As went unchanged. The pathophysiological interpretation of these findings requires further research.
Nyckelord
- Arsenic
- Organ
- Virus
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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