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  • Zhang, FanNational Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA (author)

VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis

  • Article/chapterEnglish2009

Publisher, publication year, extent ...

  • 2009-04-14
  • Proceedings of the National Academy of Sciences,2009
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-105750
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-105750URI
  • https://doi.org/10.1073/pnas.0813061106DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:118626170URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • VEGF-B, a homolog of VEGF discovered a long time ago, has not been considered an important target in antiangiogenic therapy. Instead, it has received little attention from the field. In this study, using different animal models and multiple types of vascular cells, we revealed that although VEGF-B is dispensable for blood vessel growth, it is critical for their survival. Importantly, the survival effect of VEGF-B is not only on vascular endothelial cells, but also on pericytes, smooth muscle cells, and vascular stem/progenitor cells. In vivo, VEGF-B targeting inhibited both choroidal and retinal neovascularization. Mechanistically, we found that the vascular survival effect of VEGF-B is achieved by regulating the expression of many vascular prosurvival genes via both NP-1 and VEGFR-1. Our work thus indicates that the function of VEGF-B in the vascular system is to act as a "survival," rather than an "angiogenic" factor and that VEGF-B inhibition may offer new therapeutic opportunities to treat neovascular diseases.

Subject headings and genre

  • Apoptosis
  • vascular survival
  • ocular neovascularization
  • MEDICINE
  • MEDICIN

Added entries (persons, corporate bodies, meetings, titles ...)

  • Tang, ZhongshuNational Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA (author)
  • Hou, XuNational Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA (author)
  • Lennartsson, JohanUppsala universitet,Ludwiginstitutet för cancerforskning(Swepub:uu)johalenn (author)
  • Li, YangNational Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA (author)
  • Koch, Alexander W.Neurodegeneration Labs, Protein Chemistry, Genentech, Inc. San Francisco, CA 94080, USA (author)
  • Scotney, PierreCSL Limited, Parkville, Victoria 3052, Australia (author)
  • Lee, ChunsikNational Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA (author)
  • Arjunan, PachiappanNational Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA (author)
  • Dong, LijinNational Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA (author)
  • Kumar, AnilNational Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA (author)
  • Rissanen, Tuomas T.Department of Biotechnology and Molecular Medicine, University of Kuopio, FIN-70211, Kuopio, Finland (author)
  • Wang, BinDepartment of Radiology, Medical Imaging Centre of the Affiliated Hospital, Weifang Medical University, Weifang 261042, China (author)
  • Nagai, NobuoDepartment of Physiology, Kinki University School of Medicine, Osaka 589-8511, Japan (author)
  • Fons, PierreSanofi-Aventis Recherche, Cardiovascular-Thrombosis Research Department, 31036 Toulouse Cedex, France (author)
  • Fariss, RobertNational Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA (author)
  • Zhang, YongqingTRIAD Technology Center, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA (author)
  • Wawrousek, EricNational Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA (author)
  • Tansey, GingerNational Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA (author)
  • Raber, JamesNational Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA (author)
  • Fong, Guo-HuaCenter for Vascular Biology, University of Connecticut, Farmington, CT 06030, USA (author)
  • Ding, HaoDepartment of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Canada MB R3E 3P5 (author)
  • Greenberg, David A.Buck Institute for Age Research, Novato, CA 94945, USA (author)
  • Becker, Kevin G.TRIAD Technology Center, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA (author)
  • Herbert, Jean-MarcSanofi-Aventis Recherche, Cardiovascular-Thrombosis Research Department, 31036 Toulouse Cedex, France (author)
  • Nash, AndrewCSL Limited, Parkville, Victoria 3052, Australia (author)
  • Yla-Herttuala, SeppoDepartment of Biotechnology and Molecular Medicine, University of Kuopio, FIN-70211, Kuopio, Finland (author)
  • Cao, YihaiKarolinska Institutet (author)
  • Watts, Ryan J.Neurodegeneration Labs, Protein Chemistry, Genentech, Inc. San Francisco, CA 94080; dCSL Limited, Parkville, Victoria 3052, Australia (author)
  • Li, XuriNational Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA (author)
  • National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USALudwiginstitutet för cancerforskning (creator_code:org_t)

Related titles

  • In:Proceedings of the National Academy of Sciences of the United States of America: Proceedings of the National Academy of Sciences106:15, s. 6152-61570027-84241091-6490

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