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The effect of activ...
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Martinsson, KlaraLinköpings universitet,Institutionen för klinisk och experimentell medicin,Hälsouniversitetet
(author)
The effect of activating and inhibiting Fc-receptors on murine mercury-induced autoimmunity.
- Article/chapterEnglish2008
Publisher, publication year, extent ...
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Elsevier BV,2008
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-110005
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-110005URI
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https://doi.org/10.1016/j.jaut.2008.01.002DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-19157URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Fc-receptors for IgG (Fc gamma R) link cellular and humoral immune responses, controlling the balance between activating and inhibitory immune responses, and are involved in autoimmune diseases. Mercury (Hg) induces an autoimmune condition in genetically (H-2(s,q,f)) susceptible mice characterized by lymphoproliferation, hypergammaglobulinemia and IgG antinucleolar antibodies (ANoA). Here we investigate the role of activating (Fc gamma RI, Fc gamma RIII) and inhibitory (Fc gamma RIIb) Fc-receptors on mercury-induced autoimmunity (HgIA) using DBA/1 mice (H-2(q))(-) with targeted Fc gamma R mutations and wild type (wt) mice. Mice deficient for the FcR gamma-chain or FcyRIII and treated with 15 mg/L HgCl2 showed a delayed and attenuated IgG1, IgG2a and IgG2b ANoA response compared to wt mice. Female Hg-treated FcyRIIB(-/-) mice showed a significant increased of lgG2b ANoA development compared to wt mice. The total serum IgG1 response due to Hg was attenuated in FcR gamma(-/-) and Fe gamma RIII-/- mice compared to wt mice. Hg-treated Fc gamma RIIB-/- mice showed an increase of both serum IgG1 and IgE compared to wt mice. We conclude that FcyRIII is of importance for the rapidity and final strength of the ANoA response and the increase in serum IgG1 in HgIA, while lack of Fc gamma RIIb increases the IgG2b ANoA response and the serum IgG1 and IgE response.
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Added entries (persons, corporate bodies, meetings, titles ...)
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Karlsson, LouiseLinköpings universitet,Molekylär och immunologisk patologi,Hälsouniversitetet(Swepub:liu)louka51
(author)
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Kleinau, SandraUppsala universitet,Institutionen för cell- och molekylärbiologi,Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden(Swepub:uu)sandklei
(author)
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Hultman, PerÖstergötlands Läns Landsting,Linköpings universitet,Molekylär och immunologisk patologi,Hälsouniversitetet,Klinisk patologi och klinisk genetik(Swepub:liu)perhu66
(author)
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Linköpings universitetInstitutionen för klinisk och experimentell medicin
(creator_code:org_t)
Related titles
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In:Journal of Autoimmunity: Elsevier BV31:1, s. 22-290896-84111095-9157
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