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Synthesis of C-11-l...
Synthesis of C-11-labelled metomidate analogues as adrenocortical imaging agents.
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- Karimi, Farhad (author)
- Uppsala universitet,Organisk kemi II
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- Erlandsson, Maria (author)
- Uppsala universitet,Institutionen för biokemi och organisk kemi,Organisk kemi II
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- Lindhe, Örjan (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Organisk kemi II,Endokrin tumörbiologi,Britt Skogseid
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- Långström, Bengt (author)
- Uppsala universitet,Institutionen för biokemi och organisk kemi,Organisk kemi II
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(creator_code:org_t)
- 2008
- 2008
- English.
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In: Journal of labelled compounds & radiopharmaceuticals. - : Wiley. - 0362-4803 .- 1099-1344. ; 51:6, s. 273-276:51, s. 273-276
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
Close
- Clinical findings using [C-11]methyl 1-[(1R)-1-phenylethyl]-1H-imidazole-5-carboxylate ([C-11]MTO, 1) show high uptake in lesions of adrenocortical origin, including adenomas, but low uptake in lesions of non-adrenocortical origin. In this paper the synthesis and preclinical evaluation of two new C-11-labelled analogues of MTO, [C-11]methyl 1-[(1R)-1-(4-chlorophenyl)ethyl]-1H-imidazole-5-carboxylate ([C-11]CLM, 2) and [C-11]methyl 1-[(1R)-1-(4-bromophenyl)ethyl]-1H-imidazole-5-carboxylate ([C-11]BRM, 3), using frozen-section autoradiography, organ distribution and a metabolic study are presented.
Subject headings
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
- NATURVETENSKAP -- Kemi -- Organisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Organic Chemistry (hsv//eng)
Keyword
- PET
- [C-11]methylation
- MTO
- metomidate
- adrenocortical tumours
- Chemistry
- Kemi
- Organic chemistry
Publication and Content Type
- ref (subject category)
- art (subject category)
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