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Hyaluronan-enriched...
Hyaluronan-enriched transfer medium in cleavage-stage frozen-thawed embryo transfers increases implantation rate without improvement of delivery rate
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- Hambiliki, Fredwell (author)
- Karolinska Institutet
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- Ljunger, Elisabeth (author)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Klinisk och experimentell repodruktionsbiologi/Olovsson
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- Karlström, Per-Olof (author)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Klinisk och experimentell repodruktionsbiologi/Olovsson
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- Stavreus-Evers, Anneli (author)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Klinisk och experimentell repodruktionsbiologi/Olovsson
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(creator_code:org_t)
- Elsevier BV, 2010
- 2010
- English.
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In: Fertility and Sterility. - : Elsevier BV. - 0015-0282 .- 1556-5653. ; 94:5, s. 1669-1673
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Subject headings
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- OBJECTIVE: To investigate the efficacy of hyaluronan-enriched transfer media in cleavage-stage frozen embryo transfer cycles. DESIGN: Two commercially available transfer media were prospectively compared in an observational study. SETTING: Hospital-based in vitro fertilization clinic. PATIENT(S): Patients (n = 425) undergoing frozen-thawed embryo transfer (FET). The embryos transferred were included in either a study group (high hyaluronic acid [HA], n = 199) or a control group (low HA, n = 226). INTERVENTION(S): Delivery rate per FET; positive hCG rate, biochemical pregnancy rate, clinical pregnancy rate, implantation rate, and clinical abortion rate were secondary outcomes. RESULT(S): The use of HA in the transfer media significantly increased the positive hCG rate (37.2% vs. 25.2%) and implantation rate (23.1% vs. 15.8%) without increasing the delivery rate (21.6% vs. 21.2%). More subjects in the study group with a positive hCG test experienced biochemical pregnancy (28.4% vs. 8.9%). CONCLUSION(S): Addition of HA to transfer media seems to favor attachment of early embryos in FETs without increasing the delivery rate.
Keyword
- Hyaluronan
- cryopreservation
- biochemical pregnancy
- frozen embryo transfer
- delivery rate
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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