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Disordered purinerg...
Disordered purinergic signaling inhibits pathological angiogenesis in Cd39/Entpd1-Null mice
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Jackson, Shaun W. (author)
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Hoshi, Tomakasu (author)
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Wu, Yan (author)
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Sun, Xiaofeng (author)
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Enjyoji, Keiichi (author)
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Cszimadia, Eva (author)
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- Sundberg, Christian (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Barnendokrinologisk forskning/Gustafsson
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Robson, Simon C. (author)
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(creator_code:org_t)
- Elsevier BV, 2007
- 2007
- English.
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In: American Journal of Pathology. - : Elsevier BV. - 0002-9440 .- 1525-2191. ; 171:4, s. 1395-1404
- Related links:
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.2...
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Abstract
Subject headings
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- CD39/ecto-nucleoside triphosphate diphosphohydrolase-type-1 (ENTPD1) is the dominant vascular ectonucleotidase that catalyzes the phosphohydrolysis of extracellular nucleotides in the blood and extracellular space. This ecto-enzymatic process modulates endothelial cell, leukocyte, and platelet purinergic receptor-mediated responses to extracellular nucleotides in the setting of thrombosis and vascular inflammation. We show here that deletion of Cd39/Entpd1 results in abrogation of angiogenesis, causing decreased growth of implanted tumors and inhibiting development of pulmonary metastases. Qualitative abnormalities of Cd39-null endothelial cell adhesion and integrin dysfunction were demonstrated in vitro. These changes were associated with decreased activation of focal adhesion kinase and extracellular signaling-regulated kinase-1 and -2 in endothelial cells. Our data indicate novel links between CD39/ENTPD1, extracellular nucleotide-mediated signaling, and vascular endothelial cell integrin function that impact on angiogenesis and tumor growth.
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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