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Search: onr:"swepub:oai:DiVA.org:uu-124404" > A genome-wide assoc...

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  • Marroni, Fabio (author)

A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations : the EUROSPAN project

  • Article/chapterEnglish2009

Publisher, publication year, extent ...

  • 2009
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-124404
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-124404URI
  • https://doi.org/10.1161/CIRCGENETICS.108.833806DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • BACKGROUND: We set out to identify common genetic determinants of the length of the RR and QT intervals in 2325 individuals from isolated European populations. METHODS AND RESULTS: We analyzed the heart rate at rest, measured as the RR interval, and the length of the corrected QT interval for association with 318 237 single-nucleotide polymorphisms. The RR interval was associated with common variants within GPR133, a G-protein-coupled receptor (rs885389, P=3.9 x 10(-8)). The QT interval was associated with the earlier reported NOS1AP gene (rs2880058, P=2.00 x 10(-10)) and with a region on chromosome 13 (rs2478333, P=4.34 x 10(-8)), which is 100 kb from the closest known transcript LOC730174 and has previously not been associated with the length of the QT interval. CONCLUSIONS: Our results suggested an association between the RR interval and GPR133 and confirmed an association between the QT interval and NOS1AP.

Subject headings and genre

  • genetics
  • heart rate
  • population
  • MEDICINE
  • MEDICIN

Added entries (persons, corporate bodies, meetings, titles ...)

  • Pfeufer, Arne (author)
  • Aulchenko, Yurii S. (author)
  • Franklin, Christopher S. (author)
  • Isaacs, Aaron (author)
  • Pichler, Irene (author)
  • Wild, Sarah H. (author)
  • Oostra, Ben A. (author)
  • Wright, Alan F. (author)
  • Campbell, Harry (author)
  • Witteman, Jacqueline C. (author)
  • Kääb, Stefan (author)
  • Hicks, Andrew A. (author)
  • Gyllensten, UlfUppsala universitet,Institutionen för genetik och patologi(Swepub:uu)ulfgyll (author)
  • Rudan, Igor (author)
  • Meitinger, Thomas (author)
  • Pattaro, Cristian (author)
  • van Duijn, Cornelia M. (author)
  • Wilson, James F. (author)
  • Pramstaller, Peter P. (author)
  • Uppsala universitetInstitutionen för genetik och patologi (creator_code:org_t)

Related titles

  • In:Circulation: Cardiovascular Genetics2:4, s. 322-3281942-3268

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