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A genome-wide assoc...
A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations : the EUROSPAN project
- Article/chapterEnglish2009
Publisher, publication year, extent ...
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-124404
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-124404URI
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https://doi.org/10.1161/CIRCGENETICS.108.833806DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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BACKGROUND: We set out to identify common genetic determinants of the length of the RR and QT intervals in 2325 individuals from isolated European populations. METHODS AND RESULTS: We analyzed the heart rate at rest, measured as the RR interval, and the length of the corrected QT interval for association with 318 237 single-nucleotide polymorphisms. The RR interval was associated with common variants within GPR133, a G-protein-coupled receptor (rs885389, P=3.9 x 10(-8)). The QT interval was associated with the earlier reported NOS1AP gene (rs2880058, P=2.00 x 10(-10)) and with a region on chromosome 13 (rs2478333, P=4.34 x 10(-8)), which is 100 kb from the closest known transcript LOC730174 and has previously not been associated with the length of the QT interval. CONCLUSIONS: Our results suggested an association between the RR interval and GPR133 and confirmed an association between the QT interval and NOS1AP.
Subject headings and genre
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genetics
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heart rate
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population
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MEDICINE
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MEDICIN
Added entries (persons, corporate bodies, meetings, titles ...)
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Pfeufer, Arne
(author)
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Aulchenko, Yurii S.
(author)
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Franklin, Christopher S.
(author)
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Isaacs, Aaron
(author)
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Pichler, Irene
(author)
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Wild, Sarah H.
(author)
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Oostra, Ben A.
(author)
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Wright, Alan F.
(author)
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Campbell, Harry
(author)
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Witteman, Jacqueline C.
(author)
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Kääb, Stefan
(author)
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Hicks, Andrew A.
(author)
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Gyllensten, UlfUppsala universitet,Institutionen för genetik och patologi(Swepub:uu)ulfgyll
(author)
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Rudan, Igor
(author)
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Meitinger, Thomas
(author)
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Pattaro, Cristian
(author)
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van Duijn, Cornelia M.
(author)
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Wilson, James F.
(author)
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Pramstaller, Peter P.
(author)
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Uppsala universitetInstitutionen för genetik och patologi
(creator_code:org_t)
Related titles
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In:Circulation: Cardiovascular Genetics2:4, s. 322-3281942-3268
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Marroni, Fabio
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Pfeufer, Arne
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Aulchenko, Yurii ...
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Franklin, Christ ...
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Isaacs, Aaron
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Pichler, Irene
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Wild, Sarah H.
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Oostra, Ben A.
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Wright, Alan F.
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Campbell, Harry
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Witteman, Jacque ...
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Kääb, Stefan
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Hicks, Andrew A.
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Gyllensten, Ulf
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Rudan, Igor
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Meitinger, Thoma ...
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Pattaro, Cristia ...
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van Duijn, Corne ...
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Wilson, James F.
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Pramstaller, Pet ...
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