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Molecular and Evolu...
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Anderson, Tovi M.
(author)
Molecular and Evolutionary History of Melanism in North American Gray Wolves
- Article/chapterEnglish2009
Publisher, publication year, extent ...
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American Association for the Advancement of Science (AAAS),2009
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-129895
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-129895URI
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https://doi.org/10.1126/science.1165448DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Morphological diversity within closely related species is an essential aspect of evolution and adaptation. Mutations in the Melanocortin 1 receptor (Mc1r) gene contribute to pigmentary diversity in natural populations of fish, birds, and many mammals. However, melanism in the gray wolf, Canis lupus, is caused by a different melanocortin pathway component, the K locus, that encodes a beta-defensin protein that acts as an alternative ligand for Mc1r. We show that the melanistic K locus mutation in North American wolves derives from past hybridization with domestic dogs, has risen to high frequency in forested habitats, and exhibits a molecular signature of positive selection. The same mutation also causes melanism in the coyote, Canis latrans, and in Italian gray wolves, and hence our results demonstrate how traits selected in domesticated species can influence the morphological diversity of their wild relatives.
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vonHoldt, Bridgett M.
(author)
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Candille, Sophie I.
(author)
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Musiani, Marco
(author)
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Greco, Claudia
(author)
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Stahler, Daniel R.
(author)
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Smith, Douglas W.
(author)
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Padhukasahasram, Badri
(author)
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Randi, Ettore
(author)
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Leonard, Jennifer A.Uppsala universitet,Institutionen för evolutionsbiologi,Evolutionsbiologi
(author)
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Bustamante, Carlos D.
(author)
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Ostrander, Elaine A.
(author)
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Tang, Hua
(author)
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Wayne, Robert K.
(author)
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Barsh, Gregory S.
(author)
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Uppsala universitetInstitutionen för evolutionsbiologi
(creator_code:org_t)
Related titles
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In:Science: American Association for the Advancement of Science (AAAS)323:5919, s. 1339-13430036-80751095-9203
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Anderson, Tovi M ...
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Musiani, Marco
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Greco, Claudia
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Smith, Douglas W ...
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Randi, Ettore
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Ostrander, Elain ...
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Tang, Hua
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Uppsala University