Search: onr:"swepub:oai:DiVA.org:uu-134252" > Meta-analysis ident...
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000 | 16480naa a2204105 4500 | |
001 | oai:DiVA.org:uu-134252 | |
003 | SwePub | |
008 | 101123s2010 | |||||||||||000 ||eng| | |
009 | oai:gup.ub.gu.se/127954 | |
009 | oai:lup.lub.lu.se:46e5515c-d766-40ce-8cc4-6ea53a2a0262 | |
009 | oai:prod.swepub.kib.ki.se:121530057 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1342522 URI |
024 | 7 | a https://doi.org/10.1038/ng.6852 DOI |
024 | 7 | a https://gup.ub.gu.se/publication/1279542 URI |
024 | 7 | a https://lup.lub.lu.se/record/17193192 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1215300572 URI |
040 | a (SwePub)uud (SwePub)gud (SwePub)lud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Heid, Iris M4 aut |
245 | 1 0 | a Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution |
264 | c 2010-10-10 | |
264 | 1 | b Springer Science and Business Media LLC,c 2010 |
338 | a print2 rdacarrier | |
500 | a Group Author(s): MAGIC | |
520 | a Waist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic consequences independent of overall adiposity. WHR is heritable, but few genetic variants influencing this trait have been identified. We conducted a meta-analysis of 32 genome-wide association studies for WHR adjusted for body mass index (comprising up to 77,167 participants), following up 16 loci in an additional 29 studies (comprising up to 113,636 subjects). We identified 13 new loci in or near RSPO3, VEGFA, TBX15-WARS2, NFE2L3, GRB14, DNM3-PIGC, ITPR2-SSPN, LY86, HOXC13, ADAMTS9, ZNRF3-KREMEN1, NISCH-STAB1 and CPEB4 (P = 1.9 × 10⁻⁹ to P = 1.8 × 10⁻⁴⁰) and the known signal at LYPLAL1. Seven of these loci exhibited marked sexual dimorphism, all with a stronger effect on WHR in women than men (P for sex difference = 1.9 × 10⁻³ to P = 1.2 × 10⁻¹³). These findings provide evidence for multiple loci that modulate body fat distribution independent of overall adiposity and reveal strong gene-by-sex interactions. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Fysiologi0 (SwePub)301062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Physiology0 (SwePub)301062 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Näringslära0 (SwePub)303042 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Nutrition and Dietetics0 (SwePub)303042 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
653 | a MEDICINE | |
653 | a MEDICIN | |
700 | 1 | a Jackson, Anne U4 aut |
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700 | 1 | a Alavere, Helene4 aut |
700 | 1 | a Almgren, Peteru Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-pal |
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700 | 1 | a Haritunians, Talin4 aut |
700 | 1 | a Hunter, David J4 aut |
700 | 1 | a Kaplan, Robert C4 aut |
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700 | 1 | a Cupples, L Adrienne4 aut |
700 | 1 | a Loos, Ruth J F4 aut |
700 | 1 | a Barroso, Inês4 aut |
700 | 1 | a McCarthy, Mark I4 aut |
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710 | 2 | a Karolinska Institutetb Genomik4 org |
773 | 0 | t Nature Geneticsd : Springer Science and Business Media LLCg 42:11, s. 949-960q 42:11<949-960x 1061-4036x 1546-1718 |
856 | 4 | u https://cdr.lib.unc.edu/downloads/tq57nz77f |
856 | 4 | u http://dx.doi.org/10.1038/ng.685y FULLTEXT |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-134252 |
856 | 4 8 | u https://doi.org/10.1038/ng.685 |
856 | 4 8 | u https://gup.ub.gu.se/publication/127954 |
856 | 4 8 | u https://lup.lub.lu.se/record/1719319 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:121530057 |
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