Search: onr:"swepub:oai:DiVA.org:uu-13502" >
An integrated gluco...
An integrated glucose-insulin model to describe oral glucose tolerance test data in type 2 diabetics
-
- Jauslin, Petra M (author)
- Uppsala universitet,Avdelningen för farmakokinetik och läkemedelsterapi
-
- Silber, Hanna E (author)
- Uppsala universitet,Avdelningen för farmakokinetik och läkemedelsterapi
-
Frey, Nicolas (author)
-
show more...
-
Gieschke, Ronald (author)
-
- Simonsson, Ulrika S H (author)
- Uppsala universitet,Avdelningen för farmakokinetik och läkemedelsterapi
-
Jorga, Karin (author)
-
- Karlsson, Mats O (author)
- Uppsala universitet,Avdelningen för farmakokinetik och läkemedelsterapi
-
show less...
-
(creator_code:org_t)
- 2013-03-07
- 2007
- English.
-
In: Journal of clinical pharmacology. - : Wiley. - 0091-2700 .- 1552-4604. ; 47:10, s. 1244-1255
- Related links:
-
http://www.ncbi.nlm....
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- An integrated model for the glucose-insulin system describing oral glucose tolerance test data was developed, extending on a previously introduced model for intravenous glucose provocations. Model extensions comprised the description of glucose absorption by a chain of transit compartments with a mean transit time of 35 minutes, a bioavailability of 80%, and a representation of the incretin effect, expressed as a direct effect of the glucose absorption rate on insulin secretion. The ability of the model to predict the incretin effect was assessed by simulating the observed difference in insulin response following an oral glucose tolerance test compared with an isoglycemic glucose infusion mimicking an oral glucose tolerance test profile. The extension of the integrated glucose-insulin model to gain information from oral glucose tolerance test data considerably expands its range of applications because the oral glucose tolerance test is one of the most common glucose challenge experiments for assessing the efficacy of hypoglycemic agents in clinical drug development.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Keyword
- NONMEM
- glucose homeostasis
- incretin effect
- glucagon-like peptide-1
- PHARMACY
- FARMACI
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database