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Diabetes, prediabet...
Diabetes, prediabetes and cancer mortality
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- Zhou, X. H. (author)
- Department of Public Health, University of Helsinki, PL41, Mannerheimintie 172, Helsinki, Finland
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- Qiao, Q. (author)
- Department of Public Health, University of Helsinki, PL41, Mannerheimintie 172, Helsinki, Finland
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- Zethelius, Björn (author)
- Uppsala universitet,Geriatrik,Department of Public Health/Geriatrics, Uppsala University Hospital, Uppsala, Sweden
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- Pyörälä, K. (author)
- Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
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- Söderberg, Stefan (author)
- Umeå universitet,Medicin
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- Pajak, A. (author)
- Department of Epidemiology and Population Studies, Institute of Public Health, Faculty of Health Sciences, Jagiellonian University Medical College, Krakow, Poland
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- Stehouwer, C. D. A. (author)
- Department of Internal Medicine and Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Centre, AZ Maastricht, the Netherlands
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- Heine, R. J. (author)
- EMGO Institute for Health and Care Research, VU University Medical Centre, Amsterdam, the Netherlands
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- Jousilahti, P. (author)
- Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland
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- Ruotolo, G. (author)
- Division of Metabolic and Cardiovascular Diseases, San Raffaele Scientific Institute, Milan, Italy
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- Nilsson, Peter (author)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Department of Clinical Sciences, Lund University, University Hospital, Malmö, Sweden
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- Calori, G. (author)
- Division of Metabolic and Cardiovascular Diseases, San Raffaele Scientific Institute, Milan, Italy
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- Tuomilehto, J. (author)
- South Ostrobothnia Central Hospital, Seinäjoki, Finland
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(creator_code:org_t)
- 2010-05-21
- 2010
- English.
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In: Diabetologia. - : Springer Science and Business Media LLC. - 0012-186X .- 1432-0428. ; 53:9, s. 1867-1876
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Subject headings
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- Aims/hypothesis We aimed to investigate the risk of cancer mortality in relation to the glucose tolerance status classified according to the 2 h OGTT. Methods Data from 17 European population-based or occupational cohorts involved in the DECODE study comprising 26,460 men and 18,195 women aged 25-90 years were collaboratively analysed. The cohorts were recruited between 1966 and 2004 and followed for 5.9 to 36.8 years. Cox proportional hazards analysis with adjustment for cohort, age, BMI, total cholesterol, blood pressure and smoking status was used to estimate HRs for cancer mortality. Results Compared with people in the normal glucose category, multivariable adjusted HRs (95% CI) for cancer mortality were 1.13 (1.00, 1.28), 1.27 (1.02, 1.57) and 1.71 (1.35, 2.17) in men with prediabetes, previously undiagnosed diabetes and known diabetes, respectively; in women they were 1.11 (0.94, 1.30), 1.31 (1.00, 1.70) and 1.43 (1.01, 2.02), respectively. Significant increases in deaths from cancer of the stomach, colon-rectum and liver in men with prediabetes and diabetes, and deaths from cancers of the liver and pancreas in women with diabetes were also observed. In individuals without known diabetes, the HR (95% CI) for cancer mortality corresponding to a one standard deviation increase in fasting plasma glucose was 1.06 (1.02, 1.09) and in 2 h plasma glucose was 1.07 (1.03, 1.11). Conclusions/interpretation Diabetes and prediabetes were associated with an increased risk of cancer death, particularly death from liver cancer. Mortality from all cancers rose linearly with increasing glucose concentrations.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- Cancer
- Diabetes
- Mortality
- MEDICINE
- MEDICIN
- Mortality
- Cancer
- Diabetes
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Zhou, X. H.
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Qiao, Q.
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Zethelius, Björn
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Pyörälä, K.
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Söderberg, Stefa ...
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Pajak, A.
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show more...
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Stehouwer, C. D. ...
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Heine, R. J.
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Jousilahti, P.
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Ruotolo, G.
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Nilsson, Peter
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Calori, G.
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Tuomilehto, J.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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Diabetologia
- By the university
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Uppsala University
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Lund University
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Umeå University