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Wild-type MIC distr...
Wild-type MIC distributions of four fluoroquinolones active against Mycobacterium tuberculosis in relation to current critical concentrations and available pharmacokinetic and pharmacodynamic data
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- Ängeby, Kristian A. (author)
- Karolinska Institutet,Karolinska University Hospital
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- Jureen, P. (author)
- Swedish Institute for Infectious Disease Control
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- Giske, C. G. (author)
- Karolinska Institutet,Karolinska University Hospital
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- Chryssanthou, E. (author)
- Karolinska Institutet,Karolinska University Hospital
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- Sturegård, Erik (author)
- Lund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups,Malmo University Hospital,Swedish Institute for Infectious Disease Control
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- Nordvall, Maria (author)
- Östergötlands Läns Landsting,Linköpings universitet,Pediatrik,Hälsouniversitetet,Barn- och ungdomskliniken i Linköping
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- Johansson, A. G. (author)
- Linköpings universitet,Institutionen för klinisk och experimentell medicin,Hälsouniversitetet
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- Werngren, J. (author)
- Swedish Institute for Infectious Disease Control
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- Kahlmeter, Gunnar (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,klinisk bakteriologi,Växjö Hospital
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Hoffner, S. E. (author)
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- Schön, T. (author)
- Kalmar County Hospital
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(creator_code:org_t)
- 2010-03-23
- 2010
- English.
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In: Journal of Antimicrobial Chemotherapy. - : Oxford University Press (OUP). - 0305-7453 .- 1460-2091. ; 65:5, s. 946-952
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Abstract
Subject headings
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- OBJECTIVES: To describe wild-type distributions of the MIC of fluoroquinolones for Mycobacterium tuberculosis in relation to current critical concentrations used for drug susceptibility testing and pharmacokinetic/pharmacodynamic (PK/PD) data. METHODS: A 96-stick replicator on Middlebrook 7H10 medium was used to define the MICs of ciprofloxacin, ofloxacin, moxifloxacin and levofloxacin for 90 consecutive clinical strains and 24 drug-resistant strains. The MICs were compared with routine BACTEC 460 susceptibility results and with MIC determinations in the BACTEC MGIT 960 system in a subset of strains using ofloxacin as a class representative. PK/PD data for each drug were reviewed in relation to the wild-type MIC distribution. RESULTS: The wild-type MICs of ciprofloxacin, ofloxacin, moxifloxacin and levofloxacin were distributed from 0.125 to 1, 0.25 to 1, 0.032 to 0.5 and 0.125 to 0.5 mg/L, respectively. The MIC data correlated well with the BACTEC 960 MGIT and BACTEC 460 results. PD indices were the most favourable for levofloxacin, followed by moxifloxacin, ofloxacin and ciprofloxacin. CONCLUSIONS: We propose S (susceptible)
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Keyword
- ciprofloxacin
- ofloxacin
- moxifloxacin
- levofloxacin
- susceptibility testing
- MEDICINE
- MEDICIN
- levofloxacin
- moxifloxacin
- ciprofloxacin
- ofloxacin
- susceptibility
- testing
- TECHNOLOGY
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Ängeby, Kristian ...
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Jureen, P.
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Giske, C. G.
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Chryssanthou, E.
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Sturegård, Erik
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Nordvall, Maria
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show more...
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Johansson, A. G.
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Werngren, J.
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Kahlmeter, Gunna ...
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Hoffner, S. E.
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Schön, T.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Pharmacology and ...
- Articles in the publication
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Journal of Antim ...
- By the university
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Uppsala University
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Lund University
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Karolinska Institutet
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Linköping University