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Sökning: onr:"swepub:oai:DiVA.org:uu-137416" > High PIB Retention ...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04558naa a2200565 4500 | |
| 001 | oai:DiVA.org:uu-137416 | |
| 003 | SwePub | |
| 008 | 101215s2010 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:119946235 | |
| 009 | oai:DiVA.org:su-52228 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1374162 URI |
| 024 | 7 | a https://doi.org/10.2174/1567205107902744462 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1199462352 URI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-522282 URI |
| 040 | a (SwePub)uud (SwePub)kid (SwePub)su | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Forsberg, Au Karolinska Institutet4 aut |
| 245 | 1 0 | a High PIB Retention in Alzheimer's Disease is an Early Event with Complex Relationship with CSF Biomarkers and Functional Parameters |
| 264 | 1 | b Bentham Science Publishers Ltd.c 2010 |
| 338 | a print2 rdacarrier | |
| 500 | a authorCount :6 | |
| 520 | a Background:New in vivo amyloid PET imaging tracers, such as 11C-PIB, provide possibilities to deeper understand the underlying pathological processes in Alzheimers disease (AD). In this study we investigated how 11C-PIB retention is related to cerebral glucose metabolism, episodic memory and CSF biomarkers.Method:Thirty-seven patients with mild AD and 21 patients with mild cognitive impairment (MCI) underwent PET examinations with the amyloid tracer 11C-PIB, 18F-FDG for measurement of regional cerebral metabolic rate of glucose (rCMRglc), assessment of episodic memory and assay of cerebral spinal fluid (CSF) levels of amyloid-ß (Aβ1-42), total tau and phosphorylated tau respectively. Analyses were performed using Statistical Parametric Mapping (SPM) and regions of interest (ROIs).Results:Pooled data from AD and MCI patients showed strong correlations between 11C-PIB retention, levels of CSF biomarkers (especially Aß1-42), rCMRglc and episodic memory. Analysis of the MCI group alone revealed significant correlations between 11C-PIB retention and CSF biomarkers and between CSF biomarkers and episodic memory respectively. A strong correlation was observed in the AD group between rCMRglc and episodic memory as well as a significant correlation between 11C-PIB retention and rCMRglc in some cortical regions. Regional differences were observed as sign for changes in temporal patterns across brain regions.Conclusions:A complex pattern was observed between pathological and functional markers with respect to disease stage (MCI versus AD) and brain regions. Regional differences over time were evident during disease progression. 11C-PIB PET and CSF Aß1-42 allowed detection of prodromal stages of AD. Amyloid imaging is useful for early diagnosis and evaluation of new therapeutic interventions in AD. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Radiologi och bildbehandling0 (SwePub)302082 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Radiology, Nuclear Medicine and Medical Imaging0 (SwePub)302082 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng |
| 653 | a Amyloid | |
| 653 | a CSF biomarkers | |
| 653 | a C-11-PIB-PET | |
| 653 | a F-18-FDG-PET | |
| 653 | a AD | |
| 653 | a MCI | |
| 653 | a cognition | |
| 653 | a MEDICINE | |
| 653 | a MEDICIN | |
| 653 | a SOCIAL SCIENCES | |
| 700 | 1 | a Almkvist, Oveu Stockholms universitet,Karolinska Institutet,Psykologiska institutionen4 aut0 (Swepub:su)almkv |
| 700 | 1 | a Engler, Henryu Uppsala universitet,Enheten för nuklearmedicin och PET4 aut0 (Swepub:uu)henrengl |
| 700 | 1 | a Wall, Andersu Uppsala Imanet AB, GE Healthcare, Uppsala, Sweden4 aut0 (Swepub:uu)andewall |
| 700 | 1 | a Långström, Bengtu Uppsala universitet,Institutionen för biokemi och organisk kemi4 aut0 (Swepub:uu)benglang |
| 700 | 1 | a Nordberg, A4 aut |
| 710 | 2 | a Karolinska Institutetb Psykologiska institutionen4 org |
| 773 | 0 | t Current Alzheimer Researchd : Bentham Science Publishers Ltd.g 7:1, s. 56-66q 7:1<56-66x 1567-2050x 1875-5828 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-137416 |
| 856 | 4 8 | u https://doi.org/10.2174/156720510790274446 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:119946235 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-52228 |
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- Forsberg, A
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