Sökning: onr:"swepub:oai:DiVA.org:uu-14031" >
Antibodies against ...
-
Mathsson, LindaUppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi,Autoimmunitet
(författare)
Antibodies against citrullinated vimentin in rheumatoid arthritis : Higher sensitivity and extended prognostic value concerning future radiographic progression as compared with antibodies against cyclic citrullinated peptides
- Artikel/kapitelEngelska2008
Förlag, utgivningsår, omfång ...
-
2007
-
Wiley,2008
-
printrdacarrier
Nummerbeteckningar
-
LIBRIS-ID:oai:DiVA.org:uu-14031
-
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-14031URI
-
https://doi.org/10.1002/art.23188DOI
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:116482786URI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
OBJECTIVE: The Sa autoantigen can be found in inflamed synovium of patients with rheumatoid arthritis (RA), and at least part of the humoral RA-specific anti-Sa response is directed against citrullinated vimentin. This study was undertaken to evaluate the sensitivity, specificity, and prognostic value of determination of levels of antibodies against modified citrullinated vimentin (anti-MCV) as compared with antibodies against cyclic citrullinated peptides (anti-CCP) in an inception cohort of patients with early RA. METHODS: Clinical data, radiographs, and measurements of levels of anti-MCV and anti-CCP antibodies were obtained in 273 patients with early RA at baseline, after 3 months, and after 1, 2, 3, and 5 years. Autoantibodies were also analyzed in 100 healthy controls. RESULTS: Of the 273 patients, 193 (70.7%) were anti-MCV positive and 158 (57.9%) were anti-CCP positive at the time of diagnosis, with nearly equal specificities (95% and 96%, respectively). Forty (14.7%) were anti-MCV positive only, and 5 (1.8%) were anti-CCP positive only. Anti-MCV-positive and anti-MCV-negative patients had similar disease activity at baseline, but presence of anti-MCV was predictive of subsequent high disease activity and continued radiographic progression. Changes in anti-MCV level showed stronger correlation with changes in clinical parameters than did changes in anti-CCP level. The subgroup of patients who were anti-MCV positive and anti-CCP negative showed a higher rate of radiographic destruction than did patients who were negative for both anti-MCV and anti-CCP. CONCLUSION: These findings show that when patients with early RA are compared with healthy controls, analysis of anti-MCV yields greater sensitivity and unchanged specificity as compared with analysis of anti-CCP. Anti-MCV also appears to perform better than anti-CCP in identifying poor radiographic prognosis in patients with early RA.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Mullazehi, MohammedKarolinska Institutet,Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi,Autoimmunitet(Swepub:uu)momul291
(författare)
-
Wick, Marius C
(författare)
-
Sjöberg, Olof
(författare)
-
van Vollenhoven, RonaldKarolinska Institutet
(författare)
-
Klareskog, LarsKarolinska Institutet
(författare)
-
Rönnelid, JohanUppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi,Autoimmunitet(Swepub:uu)joharonn
(författare)
-
Uppsala universitetInstitutionen för onkologi, radiologi och klinisk immunologi
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Arthritis and Rheumatism: Wiley58:1, s. 36-450004-35911529-0131
Internetlänk
Hitta via bibliotek
Till lärosätets databas