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Sökning: onr:"swepub:oai:DiVA.org:uu-140855" > Prevalence of restl...

  • Benediktsdottir, Bryndis (författare)

Prevalence of restless legs syndrome among adults in Iceland and Sweden : Lung function, comorbidity, ferritin, biomarkers and quality of life

  • Artikel/kapitelEngelska2010

Förlag, utgivningsår, omfång ...

  • Elsevier BV,2010
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-140855
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-140855URI
  • https://doi.org/10.1016/j.sleep.2010.08.006DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Objective: This study investigates the prevalence and the association between restless legs syndrome (RLS) and a large variety of health variables in two well-characterized random samples from the general population in Reykjavik, Iceland, and Uppsala, Sweden. Methods: Using the national registries of inhabitants, a random sample from adults aged 40 and over living in Reykjavík, Iceland (n= 939), and Uppsala, Sweden (n= 998), were invited to participate in a study on the prevalence of COPD (response rate 81.1% and 62.2%). In addition, the participants were asked to answer the following questionnaires: International RLS Rating Scale, Short Form-12, the Epworth Sleepiness Scale, and questions about sleep, gastroeosophageal reflux, diabetes and hypertension, as well as pharmacological treatment. Interleukin-6 (IL-6), C-reactive protein (CRP) and ferritin were measured in serum. Results: RLS was more commonly reported in Reykjavik (18.3%) than in Uppsala (11.5%). Icelandic women reported RLS almost twice as often as Swedish women (24.4 vs. 13.9% p= 0.001), but there was no difference in prevalence of RLS between Icelandic and Swedish men. RLS was strongly associated with sleep disturbances and excessive daytime sleepiness. Subjects with RLS were more likely to be ex- and current smokers than subjects without RLS (p< 0.001). Respiratory symptoms and airway obstruction were more prevalent among those reporting RLS and they also estimated their physical quality of life lower than those without RLS (p< 0.001). RLS was not associated with symptoms of the metabolic syndrome like hypertension, obesity, markers of systemic inflammation (IL-6 and CRP) or cardiovascular diseases. Ferritin levels were significantly lower in RLS participants (p= 0.0002), but not (p= 0.07) after adjustment for center, age, sex and smoking history. Conclusion: Restless legs syndrome was twice as common among Icelandic women compared to Swedish women. No such difference was seen for men. RLS was strongly associated with smoking and respiratory symptoms, decreased lung function, sleep disturbances, excessive daytime sleepiness, and physical aspects of life quality. RLS was not associated with markers of the metabolic syndrome like hypertension, obesity, cardiovascular diseases or biomarkers of systemic inflammation.

Ämnesord och genrebeteckningar

  • CRP
  • Epidemiology
  • Ferritin
  • Hypertension
  • IL-6
  • Lung function
  • Quality of life
  • Restless legs syndrome
  • MEDICINE
  • MEDICIN

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Janson, ChristerUppsala universitet,Lungmedicin och allergologi(Swepub:uu)chrisjn (författare)
  • Lindberg, EvaUppsala universitet,Lungmedicin och allergologi(Swepub:uu)evalb (författare)
  • Arnardóttir, Erna SifUppsala universitet,Lungmedicin och allergologi,Institutionen för neurovetenskap(Swepub:uu)haarn677 (författare)
  • Olafsson, Isleifur (författare)
  • Cook, Elizabeth (författare)
  • Thorarinsdottir, Elin Helga (författare)
  • Gislason, Thorarinn (författare)
  • Uppsala universitetLungmedicin och allergologi (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Sleep Medicine: Elsevier BV11:10, s. 1043-10481389-94571878-5506

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