onr:"swepub:oai:DiVA.org:uu-141123"
Search: onr:"swepub:oai:DiVA.org:uu-141123" > Antimicrobial and a...
- 1 of 1
- Previous record
- Next record
- To hitlist
- Roggen, HeidiDepartment of Chemistry, Oslo University (author)
Antimicrobial and antineoplastic activities of Agelasine analogs modified in the purine 2-position
- Article/chapterEnglish2011
Publisher, publication year, extent ...
- 2010-11-25
- Wiley,2011
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:uu-141123
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-141123URI
- https://doi.org/10.1002/ardp.201000148DOI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- Agelasines are 7,9-dialkylpurinium salts found in marine sponges (Agelas sp.), which display a variety of antimicrobial and cytotoxic effects. We have synthesized simplified agelasine analogs modified in the purine 2-position and examined their antimicrobial and anticancer activities. The compounds were screened against Staphylococcus aureus, Escherichia coli, Mycobacterium tuberculosis, Candida krusei, and Candida albicans, protozoa causing tropical diseases (Plasmodium falciparum, Leishmania infantum, Trypanosoma cruzi, and Trypanosoma brucei), a panel of human cancer cell lines (U-937 GTB, RPMI 8226/s, CEM/s, and ACHN) as well as VERO and/or MRC-5 cells. The results indicate that the introduction of a methyl group in the purine 2-position is beneficial for antimycobacterial and antiprotozoal activity, and that amino groups may enhance activity against several cancer cell lines.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Farmaceutiska vetenskaper hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Pharmaceutical Sciences hsv//eng
- Agelasine
- Antibacterial activity
- Anticancer acivitity
- Antifungal activity
- Antiprotozoal activity
- PHARMACY
- FARMACI
Added entries (persons, corporate bodies, meetings, titles ...)
- Charnock, ColinFaculty of Health Sciences, Oslo University (author)
- Burman, RobertUppsala universitet,Avdelningen för farmakognosi(Swepub:uu)burob623 (author)
- Felth, JennyUppsala universitet,Avdelningen för farmakognosi(Swepub:uu)jepet366 (author)
- Larsson, RolfUppsala universitet,Klinisk farmakologi,Cancer Pharmacology and Informatics/Rolf Larsson(Swepub:uu)rolflars (author)
- Bohlin, Lars,1948-Uppsala universitet,Avdelningen för farmakognosi(Swepub:uu)larsbohl (author)
- Gundersen, Lise-LotteDepartment of Chemistry, Oslo University (author)
- Department of Chemistry, Oslo UniversityFaculty of Health Sciences, Oslo University (creator_code:org_t)
Related titles
- In:Archiv der Pharmazie: Wiley344:1, s. 50-550365-62331521-4184
Internet link
Find in a library
- Archiv der Pharmazie (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Roggen, Heidi
- Charnock, Colin
- Burman, Robert
- Felth, Jenny
- Larsson, Rolf
- Bohlin, Lars, 19 ...
- show more...
- Gundersen, Lise- ...
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Pharmaceutical S ...
- Articles in the publication
- Archiv der Pharm ...
- By the university
- Uppsala University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
