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A multi-centre stud...
A multi-centre study of therapeutic efficacy and safety of platelet components treated with amotosalen and ultraviolet A pathogen inactivation stored for 6 or 7 d prior to transfusion
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Lozano, Miguel (author)
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- Knutson, Folke (author)
- Uppsala universitet,Klinisk immunologi,Forskargrupp Knutson
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Tardivel, Rene (author)
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Cid, Joan (author)
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Maymo, Rosa Maria (author)
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- Lööf, Helena (author)
- Uppsala universitet,Klinisk immunologi,Forskargrupp Knutson
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Roddie, Huw (author)
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Pelly, Jane (author)
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Docherty, Anthony (author)
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Sherman, Claire (author)
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Lin, Lily (author)
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Propst, Meisa (author)
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Corash, Laurence (author)
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Prowse, Chris (author)
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(creator_code:org_t)
- 2011-03-21
- 2011
- English.
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In: British Journal of Haematology. - : Wiley. - 0007-1048 .- 1365-2141. ; 153:3, s. 393-401
- Related links:
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https://onlinelibrar...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Bacteria in platelet components (PC) may result in transfusion-related sepsis (TRS). Pathogen inactivation of PC with amotosalen (A-PC) can abrogate the risk of TRS and hence facilitate storage to 7 d. A randomized, controlled, double-blinded trial to evaluate the efficacy and safety of A-PC stored for 6-7 d was conducted. Patients were randomized to receive one transfusion of conventional PC (C-PC) or A-PC stored for 6-7 d. The primary endpoint was the 1 h corrected count increment (CCI) with an acceptable inferiority of 30%. Secondary endpoints included 1- and 24-h count increment (CI), 24-h CCI, time to next PC transfusion, red blood cell (RBC) use, bleeding and adverse events. 101 and 100 patients received A-PC or C-PC respectively. The ratio of 1-h CCI (A-PC:C-PC) was 0 center dot 87 (95% confidence interval: 0 center dot 73, 1 center dot 03) demonstrating non-inferiority (P = 0 center dot 007), with respective mean 1-h CCIs of 8163 and 9383; mean 1-h CI was not significantly different. Post-transfusion bleeding and RBC use were not significantly different (P = 0 center dot 44, P = 0 center dot 82 respectively). Median time to the next PC transfusion after study PC was not significantly different between groups: (2 center dot 2 vs. 2 center dot 3 d, P = 0 center dot 72). Storage of A-PCs for 6-7 d had no impact on platelet efficacy.
Keyword
- transfusion medicine
- platelet transfusion
- pathogen inactivation
- amotosalen
- platelet storage
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Lozano, Miguel
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Knutson, Folke
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Tardivel, Rene
-
Cid, Joan
-
Maymo, Rosa Mari ...
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Lööf, Helena
-
show more...
-
Roddie, Huw
-
Pelly, Jane
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Docherty, Anthon ...
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Sherman, Claire
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Lin, Lily
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Propst, Meisa
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Corash, Laurence
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Prowse, Chris
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show less...
- Articles in the publication
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British Journal ...
- By the university
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Uppsala University