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Gene Copy Number Ab...
Gene Copy Number Aberrations Are Associated with Survival in Histologic Subgroups of Non-small Cell Lung Cancer
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- Micke, Patrick (author)
- Uppsala universitet,Molekylär och morfologisk patologi
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- Edlund, Karolina (author)
- Uppsala universitet,Molekylär och morfologisk patologi
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- Holmberg, Lars (author)
- Uppsala universitet,Endokrinkirurgi
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- Göransson Kultima, Hanna (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Cancer pharmacology and computational medicine
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- Mansouri, Larry (author)
- Uppsala universitet,Hematologi och immunologi
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- Ekman, Simon (author)
- Uppsala universitet,Enheten för onkologi
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- Bergqvist, Michael (author)
- Uppsala universitet,Enheten för onkologi
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- Scheibenflug, Lena (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi
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- Lamberg, Kristina (author)
- Uppsala universitet,Lungmedicin och allergologi
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- Myrdal, Gunnar (author)
- Uppsala universitet,Thoraxkirurgi
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Berglund, Anders (author)
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- Andersson, Annsofie (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Cancer pharmacology and computational medicine
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- Lambe, Mats (author)
- Karolinska Institutet
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- Nyberg, Fredrik, 1961 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine
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Thomas, Andrew (author)
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- Isaksson, Anders (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Cancer pharmacology and computational medicine
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- Botling, Johan (author)
- Uppsala universitet,Molekylär och morfologisk patologi
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(creator_code:org_t)
- 2011
- 2011
- English.
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In: Journal of Thoracic Oncology. - 1556-0864 .- 1556-1380. ; 6:11, s. 1833-1840
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Introduction: Non-small cell lung cancer (NSCLC) is characterized by a multitude of genetic aberrations with unknown clinical impact. In this study, we aimed to identify gene copy number changes that correlate with clinical outcome in NSCLC. To maximize the chance to identify clinically relevant events, we applied a strategy involving two prognostically extreme patient groups. Methods: Short-term (<20 month; n = 53) and long-term survivors (>58 month; n = 47) were selected from a clinically well-characterized NSCLC patient cohort with available fresh frozen tumor specimens. The samples were analyzed using high-resolution single-nucleotide polymorphism array technology to assess gene copy number variations and array-based gene expression profiling. The molecular data were combined with information on clinical parameters. Results: Genetic aberrations were strongly associated with tumor histology. In adenocarcinoma (n = 50), gene copy number gains on chromosome 8q21-q24.3 (177 genes) were more frequent in long-term than in short-term survivors. In squamous cell carcinoma (n = 28), gains on chromosome 14q23.1-24.3 (133 genes) were associated with shorter survival, whereas losses in a neighboring region, 14q31.1-32.33 (110 genes), correlated with favorable outcome. In accordance with copy number gains and losses, messenger RNA expression levels of corresponding genes were increased or decreased, respectively. Conclusion: Comprehensive tumor profiling permits the integration of genomic, histologic, and clinical data. We identified gene copy number gains and losses, with corresponding changes in messenger RNA levels that were associated with prognosis in adenocarcinoma and squamous cell carcinoma of the lung.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Keyword
- Lung cancer
- Prognosis
- SNP array
- CGH
- Gene expression profile
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Micke, Patrick
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Edlund, Karolina
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Holmberg, Lars
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Göransson Kultim ...
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Mansouri, Larry
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Ekman, Simon
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Bergqvist, Micha ...
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Scheibenflug, Le ...
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Lamberg, Kristin ...
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Myrdal, Gunnar
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Berglund, Anders
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Andersson, Annso ...
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Lambe, Mats
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Nyberg, Fredrik, ...
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Thomas, Andrew
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Isaksson, Anders
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Botling, Johan
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Respiratory Medi ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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Journal of Thora ...
- By the university
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Uppsala University
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University of Gothenburg
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Karolinska Institutet