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Putaminal Upregulat...
Putaminal Upregulation of FosB/ΔFosB-Like Immunoreactivity in Parkinson's Disease Patients with Dyskinesia
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- Lindgren, Hanna S. (författare)
- Lund University,Basal Ganglia Pathophysiology Unit
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- Rylander, D. (författare)
- Lund University,Basal Ganglia Pathophysiology Unit
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- Iderberg, H. (författare)
- Lund University,Basal Ganglia Pathophysiology Unit
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- Andersson, Malin (författare)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Neurotoxicity/Drug Safety and Toxicity
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- O'Sullivan, S. S. (författare)
- University College London,Queen Square Brain Bank
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- Williams, D. R. (författare)
- University College London,Queen Square Brain Bank
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- Lees, A. J. (författare)
- University College London,Queen Square Brain Bank
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- Cenci, M. A. (författare)
- Lund University,Basal Ganglia Pathophysiology Unit
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(creator_code:org_t)
- IOS Press, 2011
- 2011
- Engelska.
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Ingår i: Journal of Parkinson's Disease. - : IOS Press. - 1877-7171 .- 1877-718X. ; 1:4, s. 347-357
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- The transcription factor FosB is a mediator of maladaptive neuroplasticity in animal models of Parkinson´s disease (PD) and L-DOPA-induced dyskinesia. Using an antibody that recognizes all known isoforms of FosB and FosB, we have examined the expression of these proteins in post-mortem basal ganglia sections from PD patients. The patient cases were classified as being dyskinetic or non-dyskinetic based on their clinical records. Sections from neurologically healthy controls were also included in the study. Compared to both controls and non-dyskinetic cases, the dyskinetic group showed a higher density of FosB/ FosB-immunopositive cells in the posterior putamen, which represents the motor region of the striatum in primates. In contrast, the number of FosB/ FosB-positive cells did not differ significantly among the groups in the caudate, a region primarily involved with the processing of cognitive and limbic-related information. Only sparse FosB/ FosB immunoreactivity was found in the in the pallidum externum and internum, and no significant group differences were detected in these nuclei. The putaminal elevation of FosB/ FosB-like immunoreactivity in patients who had been affected by L-DOPA-induced dyskinesia is consistent with results from both rat and non-human primate models of this movement disorder. The present findings support the hypothesis of an involvement of FosB-related transcription factors in the molecular mechanisms of L-DOPA-induced dyskinesia.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- Motor complications
- immediate-early genes
- striatonigral
- striatopallidal
- medium-spiny neurons
- neurodegenera- tion
- dopaminergic therapies
- Neurology
- Neurologi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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