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Putaminal Upregulat...
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Lindgren, Hanna S.Lund University,Basal Ganglia Pathophysiology Unit
(författare)
Putaminal Upregulation of FosB/ΔFosB-Like Immunoreactivity in Parkinson's Disease Patients with Dyskinesia
- Artikel/kapitelEngelska2011
Förlag, utgivningsår, omfång ...
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IOS Press,2011
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-165526
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-165526URI
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https://doi.org/10.3233/JPD-2011-11068DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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The transcription factor FosB is a mediator of maladaptive neuroplasticity in animal models of Parkinson´s disease (PD) and L-DOPA-induced dyskinesia. Using an antibody that recognizes all known isoforms of FosB and FosB, we have examined the expression of these proteins in post-mortem basal ganglia sections from PD patients. The patient cases were classified as being dyskinetic or non-dyskinetic based on their clinical records. Sections from neurologically healthy controls were also included in the study. Compared to both controls and non-dyskinetic cases, the dyskinetic group showed a higher density of FosB/ FosB-immunopositive cells in the posterior putamen, which represents the motor region of the striatum in primates. In contrast, the number of FosB/ FosB-positive cells did not differ significantly among the groups in the caudate, a region primarily involved with the processing of cognitive and limbic-related information. Only sparse FosB/ FosB immunoreactivity was found in the in the pallidum externum and internum, and no significant group differences were detected in these nuclei. The putaminal elevation of FosB/ FosB-like immunoreactivity in patients who had been affected by L-DOPA-induced dyskinesia is consistent with results from both rat and non-human primate models of this movement disorder. The present findings support the hypothesis of an involvement of FosB-related transcription factors in the molecular mechanisms of L-DOPA-induced dyskinesia.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Rylander, D.Lund University,Basal Ganglia Pathophysiology Unit
(författare)
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Iderberg, H.Lund University,Basal Ganglia Pathophysiology Unit
(författare)
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Andersson, MalinUppsala universitet,Institutionen för farmaceutisk biovetenskap,Neurotoxicity/Drug Safety and Toxicity(Swepub:uu)malan799
(författare)
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O'Sullivan, S. S.University College London,Queen Square Brain Bank
(författare)
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Williams, D. R.University College London,Queen Square Brain Bank
(författare)
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Lees, A. J.University College London,Queen Square Brain Bank
(författare)
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Cenci, M. A.Lund University,Basal Ganglia Pathophysiology Unit
(författare)
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Lund UniversityBasal Ganglia Pathophysiology Unit
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of Parkinson's Disease: IOS Press1:4, s. 347-3571877-71711877-718X
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