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Longitudinal Stabil...
Longitudinal Stability Evaluation of Biomarkers and Their Correlation in Cerebrospinal Fluid and Plasma from Patients with Alzheimer's Disease
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Höglund, Kina, 1976 (author)
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Bogstedt, Anna (author)
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Fabre, Susanne (author)
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Aziz, Ali (author)
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- Annas, Peter (author)
- Karolinska Institutet
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- Basun, Hans (author)
- Uppsala universitet,Geriatrik
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Minthon, Lennart (author)
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- Lannfelt, Lars (author)
- Uppsala universitet,Geriatrik
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Andreasen, Niels (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2012
- 2012
- English.
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In: Journal of Alzheimer's Disease. - 1387-2877 .- 1875-8908. ; 32:4, s. 939-947
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
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- There is an increasing demand for biomarkers in clinical treatment trials to demonstrate target engagement and to support disease modification claims. To be able to detect treatment related effects, a prerequisite is that the levels of the biomarker are stable over time or that the change over time is known. In the present study, the stability of alpha- and beta-cleaved soluble amyloid-beta protein precursor (sA beta PP alpha and sA beta PP beta), A beta(1-40) together with the phosphorylated form of neurofilament heavy/medium (pNfH/M) in cerebrospinal fluid (CSF) was analyzed in a cohort of 51 patients with Alzheimer's disease. In addition, the stability of A beta(1-40), beta(1-42), and sA beta PP beta in plasma was explored. Plasma and CSF was sampled at baseline and after 6-months follow up, and all patients were on stable treatment with acetylcholinesterase inhibitors. During this 6-month longitudinal follow-up, we saw a small, but consistent and statistically significant increase in CSF levels of sA beta PP beta (103% of baseline levels) and a statistically significant decrease in the CSF levels of pNfH/M (91% of baseline levels). The mean level of the CSF biomarkers were very stable between baseline and endpoint, with within-patients coefficients of variation (CVs) of 5.84-17.3%, while the variability was larger for the plasma biomarkers, with CVs of 14.1-42.3%. This stability suggests that these biomarkers may have the potential to detect and monitor biochemical changes induced by disease-modifying drugs.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Alzheimer's disease
- biomarkers
- cerebrospinal fluid
- longitudinal
- plasma
- stability
- Alzheimer's disease
- biomarkers
- cerebrospinal fluid
- longitudinal
- plasma
- stability
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Höglund, Kina, 1 ...
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Bogstedt, Anna
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Fabre, Susanne
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Aziz, Ali
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Annas, Peter
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Basun, Hans
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show more...
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Minthon, Lennart
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Lannfelt, Lars
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Blennow, Kaj, 19 ...
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Andreasen, Niels
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Journal of Alzhe ...
- By the university
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Uppsala University
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University of Gothenburg
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Karolinska Institutet