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Autoregulation of thromboinflammation on biomaterial surfaces by a multicomponent therapeutic coating
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- Nilsson, Per H. (author)
- Linnéuniversitetet,Institutionen för kemi och biomedicin (KOB),Linnaeus Ctr Biomat Chem, BMC;HoRB
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- N. Ekdahl, Kristina (author)
- Linnéuniversitetet,Uppsala universitet,Klinisk immunologi,Institutionen för kemi och biomedicin (KOB),Uppsala University,Linnaeus Ctr Biomat Chem, BMC
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- Magnusson, Peetra U. (author)
- Uppsala universitet,Klinisk immunologi,Uppsala University
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- (creator_code:org_t)
- Elsevier BV, 2013
- 2013
- English.
- In: Biomaterials. - : Elsevier BV. - 0142-9612 .- 1878-5905. ; 34:4, s. 985-994
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Activation of the thrombotic and complement systems is the main recognition and effector mechanisms in the multiple adverse biological responses triggered when biomaterials or therapeutic cells come into blood contact. We have created a surface which is auto-protective to human innate immunity by combining three fundamentally different strategies, all developed by us previously, which have been shown to induce substantial, but incomplete hemocompatibility when used separately. In summary, we have conjugated a factor H-binding peptide; and an ADP-degrading enzyme; using a PEG linker on both material and cellular surfaces. When exposed to human whole blood, factor H was specifically recruited to the modified surfaces and inhibited complement attack. In addition, activation of platelets and coagulation was efficiently attenuated, by degrading ADP. Thus, by inhibiting thromboinflammation using a multicomponent approach, we have created a hybrid surface with the potential to greatly reduce incompatibility reactions involving biomaterials and transplantation.
Subject headings
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Keyword
- Apyrase
- Coagulation
- Complement
- Factor H-binding peptide
- Poly(ethylene glycol) (PEG)
- Surface modification
- Autoregulations
- Biological response
- Biomaterial surfaces
- Blood contact
- Complement systems
- H-binding
- Hemocompatibility
- Hybrid surface
- Innate immunity
- Modified surfaces
- Multicomponents
- Whole blood
- Biological materials
- Biomaterials
- Peptides
- Polyethylene glycols
- Surface treatment
- Surfaces
- 5C6 peptide
- biomaterial
- complement factor H
- macrogol
- peptide
- unclassified drug
- article
- autoregulation
- biotinylation
- endothelium cell
- erythrocyte
- human
- inflammation
- multicomponent therapeutic coating
- peptide synthesis
- porcine aortic endothelial cell
- priority journal
- protein immobilization
- thromboinflammation
- Biomedical Sciences
Publication and Content Type
- ref (subject category)
- art (subject category)
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- Nilsson, Per H.
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- Qu, Hongchang
- Iwata, Hiroo
- Ricklin, Daniel
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- Hong, Jaan
- Lambris, John D.
- Nilsson, Bo
- Teramura, Yuji
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- About the subject
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- Uppsala University
- Linnaeus University
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