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Combination therapy...
Combination therapy with adapalene-benzoyl peroxide and oral lymecycline in the treatment of moderate to severe acne vulgaris : a multicentre, randomized, double-blind controlled study
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Dréno, B (författare)
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Kaufmann, R (författare)
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Talarico, S (författare)
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Torres Lozada, V (författare)
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Rodríguez-Castellanos, M A (författare)
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Gómez-Flores, M (författare)
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De Maubeuge, J (författare)
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- Berg, M (författare)
- Department of Dermatology Sörmland, Mälar Hospital, Eskilstuna, Sweden
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Foley, P (författare)
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Sysa-Jedrzejowska, A (författare)
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Kerrouche, N (författare)
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Paliargues, F (författare)
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Bettoli, V (författare)
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(creator_code:org_t)
- 2011-07-06
- 2011
- Engelska.
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Ingår i: British Journal of Dermatology. - : Oxford University Press (OUP). - 0007-0963 .- 1365-2133. ; 165:2, s. 383-390
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- BACKGROUND:Oral antibiotics in association with a topical retinoid with or without benzoyl peroxide (BPO) are the recommended first-line option in the treatment of moderate to severe acne vulgaris.OBJECTIVES:To evaluate the efficacy and safety of oral lymecycline 300 mg with adapalene 0·1%-BPO 2·5% (A/BPO) fixed-dose gel in comparison with oral lymecycline 300 mg with a vehicle gel in subjects with moderate to severe acne vulgaris.METHODS:A total of 378 subjects were randomized in a double-blind, controlled trial to receive once-daily lymecycline with either A/BPO or vehicle for 12 weeks. Evaluations included percentage changes from baseline in lesion counts, success rate (subjects 'clear' or 'almost clear'), skin tolerability, adverse events and patients' satisfaction.RESULTS:The median percentage reduction from baseline in total lesion counts at week 12 was significantly higher (P < 0·001) in the lymecycline with A/BPO group (-74·1%) than in the lymecycline with vehicle group (-56·8%). The success rate was significantly higher (47·6% vs. 33·7%, P = 0·002) in subjects treated with lymecycline and A/BPO. Both inflammatory and noninflammatory lesions were significantly reduced at week 12 (both P < 0·001) with a rapid onset of action from week 2 for noninflammatory lesions (P < 0·001) and week 4 for inflammatory lesions (P = 0·005). The A/BPO and lymecycline combination was well tolerated. The proportion of satisfied and very satisfied subjects was similar in both groups, but the number in the A/BPO group who were 'very satisfied' was significantly greater (P = 0·031).CONCLUSION:These results demonstrate the clinical benefit of combining A/BPO with lymecycline in the treatment of moderate to severe acne vulgaris.
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- art (ämneskategori)
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- Av författaren/redakt...
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Dréno, B
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Kaufmann, R
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Talarico, S
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Torres Lozada, V
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Rodríguez-Castel ...
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Gómez-Flores, M
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visa fler...
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De Maubeuge, J
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Berg, M
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Foley, P
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Sysa-Jedrzejowsk ...
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Kerrouche, N
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Paliargues, F
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Bettoli, V
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visa färre...
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British Journal ...
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Uppsala universitet