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The genome of a Mes...
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Suh, AlexanderUppsala universitet,Evolutionsbiologi
(författare)
The genome of a Mesozoic paleovirus reveals the evolution of hepatitis B viruses
- Artikel/kapitelEngelska2013
Förlag, utgivningsår, omfång ...
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2013-04-30
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Springer Science and Business Media LLC,2013
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-202981
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-202981URI
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https://doi.org/10.1038/ncomms2798DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Paleovirology involves the identification of ancient endogenous viral elements within eukaryotic genomes. The evolutionary origins of the reverse-transcribing hepatitis B viruses, however, remain elusive, due to the small number of endogenized sequences present in host genomes. Here we report a comprehensively dated genomic record of hepatitis B virus endogenizations that spans bird evolution from > 82 to < 12.1 million years ago. The oldest virus relic extends over a 99% complete hepatitis B virus genome sequence and constitutes the first discovery of a Mesozoic paleovirus genome. We show that Hepadnaviridae are 463 million years older than previously known and provide direct evidence for coexistence of hepatitis B viruses and birds during the Mesozoic and Cenozoic Eras. Finally, phylogenetic analyses and distribution of hepatitis B virus relics suggest that birds potentially are the ancestral hosts of Hepadnaviridae and mammalian hepatitis B viruses probably emerged after a bird-mammal host switch. Our study reveals previously undiscovered and multi-faceted insights into prehistoric hepatitis B virus evolution and provides valuable resources for future studies, such as in-vitro resurrection of Mesozoic hepadnaviruses.
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Brosius, Juergen
(författare)
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Schmitz, Juergen
(författare)
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Kriegs, Jan Ole
(författare)
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Uppsala universitetEvolutionsbiologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Nature Communications: Springer Science and Business Media LLC4, s. 1791-2041-1723
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