Search: onr:"swepub:oai:DiVA.org:uu-207574" >
Effects of Dehydrat...
Effects of Dehydration and Blockade of the Renin-Angiotensin System in the One-humped Camel (Camelus dromedarius)
-
- Al Haj, Mahmoud (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
-
- Nyberg, Fred, Professor (thesis advisor)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
-
- Spampinato, Santi, Professor (opponent)
- University of Bologna
-
(creator_code:org_t)
- ISBN 9789155487577
- Uppsala : Acta Universitatis Upsaliensis, 2013
- English 52 s.
-
Series: Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Pharmacy, 1651-6192 ; 178
- Related links:
-
https://uu.diva-port... (primary) (Raw object)
-
show more...
-
https://uu.diva-port... (Preview)
-
https://urn.kb.se/re...
-
show less...
Abstract
Subject headings
Close
- The one-humped or the dromedarian camel is a pseudo-ruminant mammal, well adapted to the hot and dry climates of the desert. Its ability to withstand torrid heat and extreme desiccation is of paramount importance to its survival. The studies presented in this thesis were designed to investigate and document the effect of dehydration in the presence or absence of angiotensin II (Ang II) AT1 receptor blocker (losartan) on blood constituents, electrolytes, hormones, neurotransmitters as well as liver and kidney enzymes in a subset of dehydrated camels and to compare them with hydrated camels. Additionally, we studied the response of atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) and revealed for the first time the cardiac storage form of BNP in the camel heart. Dehydration induced significant increments in packed cell volume (PCV), white blood cells (WBC), gamma glutamyl-transferase (GGT), serum sodium, creatinine and urea levels, and a doubling in plasma cortisol and arginine vasopressin (AVP) levels. At the same time dehydration caused significant decrease in body weights, plasma insulin like growth factor-1 (IGF-1) and its binding protein-3 (IGFBP-3), and a 50% decrement in ANP and BNP levels. Moreover, dehydration with and without losartan resulted in significant changes in stress hormones and anti-oxidants in plasma, liver and kidney homogenates. Losartan on one hand enhanced the effect of dehydration resulting in significant increases in sodium, creatinine and urea levels. In addition losartan raised the binding affinity of Ang II AT2 receptors in the small intestine with 8-fold and with 16-fold for liver AT1 receptors, indicating that Ang II AT1 and AT2 receptor binding sites were present in camel's small intestine while only AT1 receptor binding sites were found in the camel liver. One the other hand losartan resulted in significant decrease in body weights impaired the rise in anti-diuretic hormone and reduced aldosterone level. Finally, we showed that the proBNP is the storage form of BNP in the camel heart.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Keyword
- Blood
- biochemical analysis
- catecholamine
- colorimetric assay
- cortisol
- dehydration
- dromedary camel
- glutathione
- hematological analysis
- HPLC
- insulin- like growth factor-1
- losartan
- plasma
- receptors
- radioimmunoassay
- serum
- Pharmaceutical Science
- Farmaceutisk vetenskap
Publication and Content Type
- vet (subject category)
- dok (subject category)
Find in a library
To the university's database