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A study of embryoni...
A study of embryonic stem cell-related proteins in human astrocytomas : Identification of Nanog as a predictor of survival
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- Elsir, Tamador (author)
- Karolinska Institutet,Uppsala universitet,Neurologi
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- Edqvist, Per-Henrik (author)
- Uppsala universitet,Molekylär och morfologisk patologi,Science for Life Laboratory, SciLifeLab
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- Carlson, Joseph (author)
- Karolinska Institutet
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- Ribom, Dan (author)
- Uppsala universitet,Neurologi
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- Bergqvist, Michael (author)
- Uppsala universitet,Enheten för onkologi
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- Ekman, Simon (author)
- Uppsala universitet,Enheten för onkologi
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- Popova, Svetlana N (author)
- Uppsala universitet,Molekylär och morfologisk patologi
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- Alafuzoff, Irina (author)
- Uppsala universitet,Molekylär och morfologisk patologi
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- Pontén, Fredrik (author)
- Uppsala universitet,Molekylär och morfologisk patologi,Science for Life Laboratory, SciLifeLab
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- Nistér, Monica (author)
- Karolinska Institutet
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- Smits, Anja (author)
- Uppsala universitet,Neurologi
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(creator_code:org_t)
- 2013-09-16
- 2014
- English.
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In: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 134:5, s. 1123-1131
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https://doi.org/10.1...
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Abstract
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- Recent studies suggest that the regulatory networks controlling the functions of stem cells during development may be abnormally active in human cancers. An embryonic stem cell (ESC) gene signature was found to correlate with a more undifferentiated phenotype of several human cancer types including gliomas, and associated with poor prognosis in breast cancer. In the present study, we used tissue microarrays of 80 low-grade (WHO grade II) and 98 high-grade human gliomas (WHO grade III and IV) to investigate the presence of the ESC-related proteins Nanog, Klf4, Oct4, Sox2 and c-Myc by immunohistochemistry. While similar patterns of co-expressed proteins between low- and high-grade gliomas were present, we found up-regulated protein levels of Nanog, Klf4, Oct4 and Sox2 in high-grade gliomas. Survival analysis by Kaplan-Meier analysis revealed a significant shorter survival in the subgroups of low-grade astrocytomas (n=42) with high levels of Nanog protein (p=0.0067) and of Klf4 protein (p=0.0368), in high-grade astrocytomas (n=85) with high levels of Nanog (p=0.0042), Klf4 (p=0.0447), and c-Myc (p=0.0078) and in glioblastomas only (n=71) with high levels of Nanog (p=0.0422) and of c-Myc (p= 0.0256). In the multivariate model, Nanog was identified as an independent prognostic factor in the subgroups of low-grade astrocytomas (p=0.0039), high-grade astrocytomas (p=0.0124) and glioblastomas only (p=0.0544), together with established clinical variables in these tumors. These findings provide further evidence for the joint regulatory pathways of ESC-related proteins in gliomas and identify Nanog as one of the key players in determining clinical outcome of human astrocytomas.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Elsir, Tamador
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Edqvist, Per-Hen ...
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Carlson, Joseph
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Ribom, Dan
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Bergqvist, Micha ...
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Ekman, Simon
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show more...
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Popova, Svetlana ...
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Alafuzoff, Irina
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Pontén, Fredrik
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Nistér, Monica
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Smits, Anja
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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International Jo ...
- By the university
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Uppsala University
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Umeå University
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Karolinska Institutet