Search: onr:"swepub:oai:DiVA.org:uu-214212" >
Temporal dynamics o...
-
Sutton, Lesley-AnnUppsala universitet,Institutionen för immunologi, genetik och patologi
(author)
Temporal dynamics of clonal evolution in chronic lymphocytic leukemia with stereotyped IGHV4-34/IGKV2-30 antigen receptors : longitudinal immunogenetic evidence
- Article/chapterEnglish2013
Publisher, publication year, extent ...
-
2013-08-02
-
Springer Science and Business Media LLC,2013
-
printrdacarrier
Numbers
-
LIBRIS-ID:oai:DiVA.org:uu-214212
-
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-214212URI
-
https://doi.org/10.2119/molmed.2013.00042DOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
Chronic lymphocytic leukemia (CLL) patients assigned to stereotyped subset 4 possess distinctive patterns of intraclonal diversification (ID) within their immunoglobulin (IG) genes. Although highly indicative of an ongoing response to antigen(s), the critical question concerning the precise timing of antigen involvement is unresolved. Hence, we conducted a large-scale longitudinal study of eight subset 4 cases totaling 511 and 398 subcloned IG heavy and kappa sequences. Importantly, we could establish a hierarchical pattern of subclonal evolution, thus revealing which somatic hypermutations were negatively or positively selected. In addition, distinct clusters of subcloned sequences with cluster-specific mutational profiles were observed initially; however, at later time points, the minor cluster had often disappeared and hence not been selected. Despite the high intensity of ID, it was remarkable that certain residues remained essentially unaltered. These novel findings strongly support a role for persistent antigen stimulation in the clonal evolution of CLL subset 4.
Added entries (persons, corporate bodies, meetings, titles ...)
-
Kostareli, Efterpi
(author)
-
Stalika, Evangelia
(author)
-
Tsaftaris, Athanasios
(author)
-
Anagnostopoulos, Achilles
(author)
-
Darzentas, Nikos
(author)
-
Rosenquist, RichardUppsala universitet,Institutionen för immunologi, genetik och patologi(Swepub:uu)richrose
(author)
-
Stamatopoulos, Kostas
(author)
-
Uppsala universitetInstitutionen för immunologi, genetik och patologi
(creator_code:org_t)
Related titles
-
In:Molecular Medicine: Springer Science and Business Media LLC19, s. 230-2361076-15511528-3658
Internet link
Find in a library
To the university's database