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The positive effect...
The positive effect of dietary vitamin D intake on bone mineral density in men is modulated by the polyadenosine repeat polymorphism of the vitamin D receptor
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- Michaëlsson, Karl (author)
- Uppsala universitet,Ortopedi
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- Wolk, Alicja (author)
- Karolinska Institutet
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- Jacobsson, Annica (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Clinical pharmacogenetics and Osteoporosis
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- Kindmark, Andreas, 1967- (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Metabolic Bone Diseases
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- Grundberg, Elin (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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- Stiger, Fredrik (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Clinical pharmacogenetics and Osteoporosis
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- Mallmin, Hans (author)
- Uppsala universitet,Ortopedi
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- Ljunghall, Sverker (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,osteoporosis
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- Melhus, Håkan (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Clinical pharmacogenetics and Osteoporosis
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(creator_code:org_t)
- Elsevier BV, 2006
- 2006
- English.
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In: Bone. - : Elsevier BV. - 8756-3282 .- 1873-2763. ; 39:6, s. 1343-1351
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- INTRODUCTION: Few studies have considered the dietary influence of vitamin D intake on bone mineral density (BMD). Numerous studies have examined the association between VDR polymorphism and BMD, but no previous study has examined the joint influence of dietary vitamin D intake and VDR polymorphism on BMD. METHODS: We therefore conducted a study in 230 men aged 41-76 years of age. BMD was measured with DXA. A second bone scan was performed on average 2.7 years after the first investigation. Dietary habits were assessed by 14 dietary 24-h recall interviews. The polyadenosine (A) VDR genotypes were determined. RESULTS: Dietary vitamin D intake was associated with BMD at all sites, also after multivariate adjustment. Those in the highest quintile of intake had 9% higher femoral neck BMD (p = 0.004), 6% higher BMD at the lumbar spine (p = 0.06) and 5% higher total body BMD (p = 0.003) compared to men in the lowest quintile of dietary vitamin D intake. However, the positive association between vitamin D intake and BMD was especially apparent among those with the L/L polyadenosine (A) VDR genotype explaining between 10 and 15% of the variability in BMD depending on site (p < 0.004). There was furthermore a trend, in the lumbar spine, of less reduction in BMD with increasing vitamin D intake (p = 0.07) but not at the other sites. Calcium intake conferred no association with BMD. CONCLUSIONS: Our results indicate that the extent of positive association between dietary vitamin D intake and BMD in men is dependent on VDR polymorphism, a novel conceivable important gene-environmental interaction.
Keyword
- Bone mineral density
- Vitamin D
- Diet
- VDR
- Calcium
- Polymorphism
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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