Sökning: onr:"swepub:oai:DiVA.org:uu-228467" >
Mosaic loss of chro...
-
Forsberg, Lars A.Uppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik
(author)
Mosaic loss of chromosome Y in peripheral blood is associated with shorter survival and higher risk of cancer
- Article/chapterEnglish2014
Publisher, publication year, extent ...
-
2014-04-28
-
Springer Science and Business Media LLC,2014
-
printrdacarrier
Numbers
-
LIBRIS-ID:oai:DiVA.org:uu-228467
-
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-228467URI
-
https://doi.org/10.1038/ng.2966DOI
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:129149232URI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
Incidence and mortality for sex-unspecific cancers are higher among men, a fact that is largely unexplained(1,2). Furthermore, age-related loss of chromosome Y (LOY) is frequent in normal hematopoietic cells(3,4), but the phenotypic consequences of LOY have been elusive(5-10). From analysis of 1,153 elderly men, we report that LOY in peripheral blood was associated with risks of all-cause mortality (hazards ratio (HR) = 1.91, 95% confidence interval (CI) = 1.17-3.13; 637 events) and non-hematological cancer mortality (HR = 3.62, 95% CI = 1.56-8.41; 132 events). LOY affected at least 8.2% of the subjects in this cohort, and median survival times among men with LOY were 5.5 years shorter. Association of LOY with risk of all-cause mortality was validated in an independent cohort (HR = 3.66) in which 20.5% of subjects showed LOY. These results illustrate the impact of post-zygotic mosaicism on disease risk, could explain why males are more frequently affected by cancer and suggest that chromosome Y is important in processes beyond sex determination. LOY in blood could become a predictive biomarker of male carcinogenesis.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Rasi, ChiaraUppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik(Swepub:uu)chira497
(author)
-
Malmqvist, NiklasUppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för medicinska vetenskaper,Medicinsk genetik och genomik
(author)
-
Davies, HannaUppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik(Swepub:uu)handa349
(author)
-
Pasupulati, SaichandUppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för immunologi, genetik och patologi
(author)
-
Pakalapati, GeetaUppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab
(author)
-
Sandgren, JohannaKarolinska Institutet
(author)
-
de Stahl, Teresita DiazKarolinska Institutet
(author)
-
Zaghlool, AmmarUppsala universitet,Science for Life Laboratory, SciLifeLab,Genomik(Swepub:uu)ammza789
(author)
-
Giedraitis, VilmantasUppsala universitet,Geriatrik(Swepub:uu)vigie517
(author)
-
Lannfelt, LarsUppsala universitet,Geriatrik(Swepub:uu)lalan021
(author)
-
Score, Joannah
(author)
-
Cross, Nicholas C. P.
(author)
-
Absher, Devin
(author)
-
Tiensuu Janson, EvaUppsala universitet,Onkologisk endokrinologi(Swepub:uu)evatieja
(author)
-
Lindgren, Cecilia M.
(author)
-
Morris, Andrew P.
(author)
-
Ingelsson, ErikUppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)ering425
(author)
-
Lind, LarsUppsala universitet,Kardiovaskulär epidemiologi(Swepub:uu)larslind
(author)
-
Dumanski, Jan P.Uppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik(Swepub:uu)janduman
(author)
-
Uppsala universitetScience for Life Laboratory, SciLifeLab
(creator_code:org_t)
Related titles
-
In:Nature Genetics: Springer Science and Business Media LLC46:6, s. 624-6281061-40361546-1718
Internet link
Find in a library
To the university's database
- By the author/editor
-
Forsberg, Lars A ...
-
Rasi, Chiara
-
Malmqvist, Nikla ...
-
Davies, Hanna
-
Pasupulati, Saic ...
-
Pakalapati, Geet ...
-
show more...
-
Sandgren, Johann ...
-
de Stahl, Teresi ...
-
Zaghlool, Ammar
-
Giedraitis, Vilm ...
-
Lannfelt, Lars
-
Score, Joannah
-
Cross, Nicholas ...
-
Absher, Devin
-
Tiensuu Janson, ...
-
Lindgren, Cecili ...
-
Morris, Andrew P ...
-
Ingelsson, Erik
-
Lind, Lars
-
Dumanski, Jan P.
-
show less...
- About the subject
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
and Medicinska och f ...
-
and Medicinsk geneti ...
- Articles in the publication
-
Nature Genetics
- By the university
-
Uppsala University
-
Karolinska Institutet