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  • Forsberg, Lars A.Uppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik (author)

Mosaic loss of chromosome Y in peripheral blood is associated with shorter survival and higher risk of cancer

  • Article/chapterEnglish2014

Publisher, publication year, extent ...

  • 2014-04-28
  • Springer Science and Business Media LLC,2014
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-228467
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-228467URI
  • https://doi.org/10.1038/ng.2966DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:129149232URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Incidence and mortality for sex-unspecific cancers are higher among men, a fact that is largely unexplained(1,2). Furthermore, age-related loss of chromosome Y (LOY) is frequent in normal hematopoietic cells(3,4), but the phenotypic consequences of LOY have been elusive(5-10). From analysis of 1,153 elderly men, we report that LOY in peripheral blood was associated with risks of all-cause mortality (hazards ratio (HR) = 1.91, 95% confidence interval (CI) = 1.17-3.13; 637 events) and non-hematological cancer mortality (HR = 3.62, 95% CI = 1.56-8.41; 132 events). LOY affected at least 8.2% of the subjects in this cohort, and median survival times among men with LOY were 5.5 years shorter. Association of LOY with risk of all-cause mortality was validated in an independent cohort (HR = 3.66) in which 20.5% of subjects showed LOY. These results illustrate the impact of post-zygotic mosaicism on disease risk, could explain why males are more frequently affected by cancer and suggest that chromosome Y is important in processes beyond sex determination. LOY in blood could become a predictive biomarker of male carcinogenesis.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Rasi, ChiaraUppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik(Swepub:uu)chira497 (author)
  • Malmqvist, NiklasUppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för medicinska vetenskaper,Medicinsk genetik och genomik (author)
  • Davies, HannaUppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik(Swepub:uu)handa349 (author)
  • Pasupulati, SaichandUppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för immunologi, genetik och patologi (author)
  • Pakalapati, GeetaUppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab (author)
  • Sandgren, JohannaKarolinska Institutet (author)
  • de Stahl, Teresita DiazKarolinska Institutet (author)
  • Zaghlool, AmmarUppsala universitet,Science for Life Laboratory, SciLifeLab,Genomik(Swepub:uu)ammza789 (author)
  • Giedraitis, VilmantasUppsala universitet,Geriatrik(Swepub:uu)vigie517 (author)
  • Lannfelt, LarsUppsala universitet,Geriatrik(Swepub:uu)lalan021 (author)
  • Score, Joannah (author)
  • Cross, Nicholas C. P. (author)
  • Absher, Devin (author)
  • Tiensuu Janson, EvaUppsala universitet,Onkologisk endokrinologi(Swepub:uu)evatieja (author)
  • Lindgren, Cecilia M. (author)
  • Morris, Andrew P. (author)
  • Ingelsson, ErikUppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)ering425 (author)
  • Lind, LarsUppsala universitet,Kardiovaskulär epidemiologi(Swepub:uu)larslind (author)
  • Dumanski, Jan P.Uppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik(Swepub:uu)janduman (author)
  • Uppsala universitetScience for Life Laboratory, SciLifeLab (creator_code:org_t)

Related titles

  • In:Nature Genetics: Springer Science and Business Media LLC46:6, s. 624-6281061-40361546-1718

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