Search: onr:"swepub:oai:DiVA.org:uu-229388" >
Immunotherapy targe...
Immunotherapy targeting alpha-synuclein, with relevance for future treatment of Parkinson's disease and other Lewy body disorders
-
- Lindström, Veronica (author)
- Uppsala universitet,Geriatrik
-
- Ihse, Elisabet (author)
- Uppsala universitet,Geriatrik
-
- Fagerqvist, Therese (author)
- Uppsala universitet,Geriatrik
-
show more...
-
- Bergström, Joakim (author)
- Uppsala universitet,Geriatrik
-
Nordstrom, Eva (author)
-
Moller, Christer (author)
-
- Lannfelt, Lars (author)
- Uppsala universitet,Geriatrik
-
- Ingelsson, Martin (author)
- Uppsala universitet,Geriatrik
-
show less...
-
(creator_code:org_t)
- 2014
- 2014
- English.
-
In: Immunotherapy. - 1750-743X .- 1750-7448. ; 6:2, s. 141-153
- Related links:
-
https://urn.kb.se/re...
-
show more...
-
https://doi.org/10.2...
-
show less...
Abstract
Subject headings
Close
- Immunotherapy targeting a-synuclein has evolved as a potential therapeutic strategy for neurodegenerative diseases, such as Parkinson's disease, and initial studies on cellular and animal models have shown promising results. alpha-synuclein vaccination of transgenic mice reduced the number of brain inclusions, whereas passive immunization studies demonstrated that antibodies against the C-terminus of alpha-synuclein can pass the blood-brain barrier and affect the pathology. In addition, preliminary evidence suggests that transgenic mice treated with an antibody directed against alpha-synuclein oligomers/protofibrils resulted in reduced levels of such species in the CNS. The underlying mechanisms of immunotherapy are not yet fully understood, but may include antibody-mediated clearance of pre-existing aggregates, prevention of protein propagation between cells and microglia-dependent protein clearance. Thus, immunotherapy targeting alpha-synuclein holds promise, but needs to be further developed as a future disease-modifying treatment in Parkinson's disease and other alpha-synucleinopathies.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- alpha-synuclein
- antibody
- immunization
- immunotherapy
- Parkinson's disease
Publication and Content Type
- ref (subject category)
- for (subject category)
Find in a library
To the university's database