SwePub
Sök i LIBRIS databas

  Extended search

onr:"swepub:oai:DiVA.org:uu-230112"
 

Search: onr:"swepub:oai:DiVA.org:uu-230112" > Insulin signaling t...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Insulin signaling to the glomerular podocyte is critical for normal kidney function

Welsh, Gavin I (author)
Hale, Lorna J (author)
Eremina, Vera (author)
show more...
Jeansson, Marie (author)
Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
Maezawa, Yoshiro (author)
Lennon, Rachel (author)
Pons, Deborah A (author)
Owen, Rachel J (author)
Satchell, Simon C (author)
Miles, Mervyn J (author)
Caunt, Christopher J (author)
McArdle, Craig A (author)
Pavenstädt, Hermann (author)
Tavaré, Jeremy M (author)
Herzenberg, Andrew M (author)
Kahn, C Ronald (author)
Mathieson, Peter W (author)
Quaggin, Susan E (author)
Saleem, Moin A (author)
Coward, Richard J M (author)
show less...
 (creator_code:org_t)
Elsevier BV, 2010
2010
English.
In: Cell Metabolism. - : Elsevier BV. - 1550-4131 .- 1932-7420. ; 12:4, s. 329-340
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • Diabetic nephropathy (DN) is the leading cause of renal failure in the world. It is characterized by albuminuria and abnormal glomerular function and is considered a hyperglycemic "microvascular" complication of diabetes, implying a primary defect in the endothelium. However, we have previously shown that human podocytes have robust responses to insulin. To determine whether insulin signaling in podocytes affects glomerular function in vivo, we generated mice with specific deletion of the insulin receptor from their podocytes. These animals develop significant albuminuria together with histological features that recapitulate DN, but in a normoglycemic environment. Examination of "normal" insulin-responsive podocytes in vivo and in vitro demonstrates that insulin signals through the MAPK and PI3K pathways via the insulin receptor and directly remodels the actin cytoskeleton of this cell. Collectively, this work reveals the critical importance of podocyte insulin sensitivity for kidney function.

Publication and Content Type

ref (subject category)
art (subject category)

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view