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Severe vitamin D de...
Severe vitamin D deficiency is associated with frequent exacerbations and hospitalization in COPD patients
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- Malinovschi, Andrei (författare)
- Uppsala universitet,Klinisk fysiologi
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Masoero, Monica (författare)
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Bellocchia, Michela (författare)
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Ciuffreda, Antonio (författare)
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Solidoro, Paolo (författare)
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Mattei, Alessio (författare)
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Mercante, Lorena (författare)
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Heffler, Enrico (författare)
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Rolla, Giovanni (författare)
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Bucca, Caterina (författare)
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(creator_code:org_t)
- 2014-12-13
- 2014
- Engelska.
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Ingår i: Respiratory Research. - : Springer Science and Business Media LLC. - 1465-9921 .- 1465-993X. ; 15, s. 131-
- Relaterad länk:
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https://uu.diva-port... (primary) (Raw object)
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https://respiratory-...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Background: Acute exacerbations of COPD (AECOPD) are common and strongly influence disease severity and relative healthcare costs. Vitamin D deficiency is frequent among COPD patients and its contributory role in disease exacerbations is widely debated. Our aim was to assess the relationship of serum vitamin D levels with COPD severity and AECOPD. Methods: Serum vitamin D (25-hydroxyvitamin D) levels were measured in 97 COPD patients and related to lung function, comorbidities, FEV1 decline, AECOPD and hospital admission during the previous year. Results: Most patients (96%) had vitamin D deficiency, which was severe in 35 (36%). No significant relationship was found between vitamin D and FEV1 or annual FEV1 decline. No difference between patients with and without severe vitamin D deficiency was found in age, gender, BMI, smoking history, lung function, and comorbidities, apart from osteoporosis (60.9% in severe deficiency vs 22.7%, p = 0.001). In multiple logistic regression models, severe deficiency was independently associated with AECOPD [adjusted odds ratios (aOR) of 30.5 (95% CI 5.55, 168), p < 0.001] and hospitalization [aOR 3.83 (95% CI 1.29, 11.4), p = 0.02]. The odds ratio of being a frequent exacerbator if having severe vitamin D deficiency was 18.1 (95% CI 4.98, 65.8) (p < 0.001), while that of hospitalization was 4.57 (95% CI 1.83, 11.4) (p = 0.001). Conclusions: In COPD patients severe vitamin D deficiency was related to more frequent disease exacerbations and hospitalization during the year previous to the measurement of vitamin D. This association was independent of patients' characteristics and comorbidities.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Nyckelord
- Vitamin D
- COPD
- COPD exacerbation
- Hospitalization
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Malinovschi, And ...
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Masoero, Monica
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Bellocchia, Mich ...
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Ciuffreda, Anton ...
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Solidoro, Paolo
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Mattei, Alessio
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visa fler...
-
Mercante, Lorena
-
Heffler, Enrico
-
Rolla, Giovanni
-
Bucca, Caterina
-
visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Lungmedicin och ...
- Artiklar i publikationen
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Respiratory Rese ...
- Av lärosätet
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Uppsala universitet