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Microsatellite inst...
Microsatellite instability and mutations in BRAF and KRAS are significant predictors of disseminated disease in colon cancer
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- Birgisson, Helgi (author)
- Uppsala universitet,Kolorektalkirurgi
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- Edlund, Karolina (author)
- Uppsala universitet,Molekylär och morfologisk patologi
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- Wallin, Ulrik (author)
- Uppsala universitet,Kolorektalkirurgi
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- Påhlman, Lars (author)
- Uppsala universitet,Kolorektalkirurgi
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- Kultima, Hanna Göransson (author)
- Uppsala universitet,Cancerfarmakologi och beräkningsmedicin,Science for Life Laboratory, SciLifeLab
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- Mayrhofer, Markus (author)
- Uppsala universitet,Cancerfarmakologi och beräkningsmedicin,Science for Life Laboratory, SciLifeLab
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- Micke, Patrick (author)
- Uppsala universitet,Molekylär och morfologisk patologi
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- Isaksson, Anders (author)
- Uppsala universitet,Cancerfarmakologi och beräkningsmedicin,Science for Life Laboratory, SciLifeLab
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- Botling, Johan (author)
- Uppsala universitet,Molekylär och morfologisk patologi
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- Glimelius, Bengt (author)
- Uppsala universitet,Experimentell och klinisk onkologi
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- Sundström, Magnus (author)
- Uppsala universitet,Molekylär och morfologisk patologi
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(creator_code:org_t)
- 2015-03-14
- 2015
- English.
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In: BMC Cancer. - : Springer Science and Business Media LLC. - 1471-2407. ; 15
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https://uu.diva-port... (primary) (Raw object)
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Abstract
Subject headings
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- Background: Molecular alterations are well studied in colon cancer, however there is still need for an improved understanding of their prognostic impact. This study aims to characterize colon cancer with regard to KRAS, BRAF, and PIK3CA mutations, microsatellite instability (MSI), and average DNA copy number, in connection with tumour dissemination and recurrence in patients with colon cancer. Methods: Disease stage II-IV colon cancer patients (n = 121) were selected. KRAS, BRAF, and PIK3CA mutation status was assessed by pyrosequencing and MSI was determined by analysis of mononucleotide repeat markers. Genome-wide average DNA copy number and allelic imbalance was evaluated by SNP array analysis. Results: Patients with mutated KRAS were more likely to experience disease dissemination (OR 2.75; 95% CI 1.28-6.04), whereas the opposite was observed for patients with BRAF mutation (OR 0.34; 95% 0.14-0.81) or MSI (OR 0.24; 95% 0.09-0.64). Also in the subset of patients with stage II-III disease, both MSI (OR 0.29; 95% 0.10-0.86) and BRAF mutation (OR 0.32; 95% 0.16-0.91) were related to lower risk of distant recurrence. However, average DNA copy number and PIK3CA mutations were not associated with disease dissemination. Conclusions: The present study revealed that tumour dissemination is less likely to occur in colon cancer patients with MSI and BRAF mutation, whereas the presence of a KRAS mutation increases the likelihood of disseminated disease.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Colon cancer
- MSI
- BRAF
- KRAS
- PIK3CA
- DNA copy number
- Prognosis
Publication and Content Type
- ref (subject category)
- art (subject category)
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BMC Cancer
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To the university's database
- By the author/editor
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Birgisson, Helgi
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Edlund, Karolina
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Wallin, Ulrik
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Påhlman, Lars
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Kultima, Hanna G ...
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Mayrhofer, Marku ...
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show more...
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Micke, Patrick
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Isaksson, Anders
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Botling, Johan
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Glimelius, Bengt
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Sundström, Magnu ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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BMC Cancer
- By the university
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Uppsala University