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Lithium as a Treatm...
Lithium as a Treatment for Alzheimer's Disease : A Systematic Review and Meta-Analysis
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- Matsunaga, Shinji (författare)
- Fujita Hlth Univ, Sch Med, Dept Psychiat, Toyoake, Aichi 4701192, Japan.
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- Kishi, Taro (författare)
- Fujita Hlth Univ, Sch Med, Dept Psychiat, Toyoake, Aichi 4701192, Japan.
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- Annas, Peter (författare)
- Karolinska Institutet,Uppsala universitet,Institutionen för psykologi
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- Basun, Hans (författare)
- Uppsala universitet,Geriatrik
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- Hampel, Harald (författare)
- Univ Paris 06, AXA Res Fund, Univ Paris 04, Inst Memoire & Malad Alzheimer, Paris, France.;Univ Paris 06, UPMC Chair, Univ Paris 04, Inst Memoire & Malad Alzheimer, Paris, France.;Hop La Pitie Salpetriere, INSERM U1127, Inst Cerveau & Moelle Epiniere ICM, Dept Neurol, Paris, France.
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- Iwata, Nakao (författare)
- Fujita Hlth Univ, Sch Med, Dept Psychiat, Toyoake, Aichi 4701192, Japan.
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Fujita Hlth Univ, Sch Med, Dept Psychiat, Toyoake, Aichi 4701192, Japan Institutionen för psykologi (creator_code:org_t)
- 2015
- 2015
- Engelska.
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Ingår i: Journal of Alzheimer's Disease. - 1387-2877 .- 1875-8908. ; 48:2, s. 403-410
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.3...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background: This is the first meta-analysis of randomized placebo-controlled trials testing lithium as a treatment for patients with Alzheimer's disease (AD) and individuals with mild cognitive impairment (MCI). Methods: The primary outcome measure was efficacy on cognitive performance as measured through the Alzheimer's Disease Assessment Scale cognitive subscale or the Mini-Mental State Examination. Other outcome measures were drug discontinuation rate, individual side effects, and biological markers (phosphorylated tau 181, total tau, and amyloid-beta(42)) in cerebrospinal fluid (CSF). Results: Three clinical trials including 232 participants that met the study's inclusion criteria were identified. Lithium significantly decreased cognitive decline as compared to placebo (standardized mean difference = -0.41, 95% confidence interval = -0.81 to -0.02, p = 0.04, I-2 = 47%, 3 studies, n = 199). There were no significant differences in the rate of attrition, discontinuation due to all causes or adverse events, or CSF biomarkers between treatment groups. Conclusions: The results indicate that lithium treatment may have beneficial effects on cognitive performance in subjects with MCI and AD dementia.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Alzheimer's disease
- lithium
- meta-analysis
- mild cognitive impairment
- systematic review
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
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