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Control of growth factor binding and release in bisphosphonate functionalized hydrogels guides rapid diff erentiation of precursor cells in vitro

Kootala, Sujit, Researcher, 1981- (author)
Uppsala universitet,Polymerkemi,Science for Life Laboratory, SciLifeLab,Jöns Hilborn/Biomaterials
Zhang, Yu (author)
Uppsala universitet,Polymerkemi,Science for Life Laboratory, SciLifeLab,Jöns Hilborn/Biomaterials
Ghalib, Sara (author)
Uppsala universitet,Polymerkemi
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Tolmachev, Vladimir (author)
Uppsala universitet,Medicinsk strålningsvetenskap
Hilborn, Jöns, 1956- (author)
Uppsala universitet,Polymerkemi,Science for Life Laboratory, SciLifeLab,Jöns Hilborn/Biomaterials
Ossipov, Dmitri A. (author)
Uppsala universitet,Polymerkemi,Science for Life Laboratory, SciLifeLab,Jöns Hilborn/Biomaterials
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 (creator_code:org_t)
2016
2016
English.
In: Biomaterials Science. - UK : Royal Society of Chemistry. - 2047-4830 .- 2047-4849. ; 4:2, s. 250-254
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • An in situ cross-linkable hyaluronan hydrogel functionalized with bisphosphonate (BP) groups allows tunable release of bone morphogenetic protein-2 (BMP-2) determined by the amount of BP groups. The high affinity of matrix-anchored BP groups towards BMP-2 permits guided differentiation of entrapped progenitor cells in 3-D cultures.

Subject headings

NATURVETENSKAP  -- Kemi -- Polymerkemi (hsv//swe)
NATURAL SCIENCES  -- Chemical Sciences -- Polymer Chemistry (hsv//eng)

Keyword

bone
hyaluronic acid
bisphosphonates
growth factor
delivery
stem cells
Kemi med inriktning mot materialkemi
Chemistry with specialization in Materials Chemistry
Kemi med inriktning mot polymerkemi
Chemistry with specialization in Polymer Chemistry
Biology with specialization in Molecular Biology
Biologi med inriktning mot molekylärbiologi

Publication and Content Type

ref (subject category)
art (subject category)

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