Antibacterial effect of the red sea soft coral Sarcophyton trocheliophorum

Gomaa, Mohamed N. (author): King Abdulaziz Univ, Fac Sci & Arts Khulais, Dept Biol, Khulais, Saudi Arabia.

Soliman, Kawther (author): King Abdulaziz Univ, Fac Sci & Arts Khulais, Dept Biol, Khulais, Saudi Arabia.

Ayesh, Ahmed (author): King Abdulaziz Univ, Fac Sci & Arts Khulais, Dept Biol, Khulais, Saudi Arabia.

Abd El-Wahed, Aida (author): Uppsala universitet,Avdelningen för farmakognosi

Hamza, Zeinab (author): Natl Res Ctr, Food Toxins & Contaminants Dept, Marine Toxins Lab, Cairo, Egypt.

Mansour, Hager M. (author): Univ Karachi, HEJ Res Inst Chem, Int Ctr Chem Sci, Karachi 75270, Pakistan.

Khalifa, Shaden A. M. (author): Karolinska Univ Hosp, Dept Expt Hematol, SE-14186 Stockholm, Sweden.

Mohd Ali, Hapipah Bint (author): Univ Malaya, Dept Chem, Ctr Nat Prod & Drug Discovery CENAR, Fac Sci, Kuala Lumpur 50603, Malaysia.

El-Seedi, Hesham R. (author): Uppsala universitet,Avdelningen för farmakognosi,Karolinska Univ Hosp, Dept Expt Hematol, SE-14186 Stockholm, Sweden.;Univ Malaya, Dept Chem, Ctr Nat Prod & Drug Discovery CENAR, Fac Sci, Kuala Lumpur 50603, Malaysia.

King Abdulaziz Univ, Fac Sci & Arts Khulais, Dept Biol, Khulais, Saudi Arabia Avdelningen för farmakognosi (creator_code:org_t)

2015-07-17
2016
English.
In: Natural Product Research. - : Informa UK Limited. - 1478-6419 .- 1478-6427. ; 30:6, s. 729-734

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Abstract Subject headings

The marine soft corals Sarcophyton trocheliophorum crude extracts possessed antimicrobial activity towards pathogenic bacterial strains, i.e. Bacillus cereus, Salmonella typhi, Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa. Bioassay-guided fractionation indicated that the antimicrobial effect was due to the presence of terpenoid bioactive derivatives. Further biological assays of the n-hexane fractions were carried out using turbidity assay, inhibition zone assay and minimum inhibitory concentration for investigating the growth-inhibition effect towards the Gram-positive and Gram-negative bacteria. The fractions were screened and the structure of the isolated compound was justified by interpretation of the spectroscopic data, mainly mass spectrometry (GC-MS). The structure was assigned as (5S)-3-[(3E,5S)-5-hydroxy-3-hepten-6-yn-1-yl]-5-methyl-2(5H)-furanone and was effective at concentrations as low as 0.20mg/mL. The above findings, in the course of our ongoing research on marine products, may implicate that the profound anti-microbial activity of the S. trocheliophorum soft corals, inhabiting the red sea reefs, is attributed to the presence of growth-inhibiting secondary metabolites mainly terpenoids.

By the author/editor: Gomaa, Mohamed N ...; Soliman, Kawther; Ayesh, Ahmed; Abd El-Wahed, Ai ...; Hamza, Zeinab; Mansour, Hager M ...; show more...; Khalifa, Shaden ...; Mohd Ali, Hapipa ...; El-Seedi, Hesham ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Pharmacology and ...

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