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IGF-1 degradation b...
IGF-1 degradation by mouse mast cell protease 4 promotes cell death and adverse cardiac remodeling days after a myocardial infarction
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- Tejada, Thor (author)
- Emory Univ, Sch Med, Dept Med Cardiol, Atlanta, GA 30322 USA.
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- Tan, Lin (author)
- Emory Univ, Sch Med, Dept Med Cardiol, Atlanta, GA 30322 USA.
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- Torres, Rebecca A. (author)
- Emory Univ, Sch Med, Dept Med Cardiol, Atlanta, GA 30322 USA.
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- Calvert, John W. (author)
- Emory Univ, Sch Med, Dept Surg, Carlyle Fraser Heart Ctr, Atlanta, GA 30322 USA.
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- Lambert, Jonathan P. (author)
- Emory Univ, Sch Med, Dept Surg, Carlyle Fraser Heart Ctr, Atlanta, GA 30322 USA.
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- Zaidi, Madiha (author)
- Emory Univ, Sch Med, Dept Med Cardiol, Atlanta, GA 30322 USA.
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- Husain, Murtaza (author)
- Emory Univ, Sch Med, Dept Med Cardiol, Atlanta, GA 30322 USA.
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- Berce, Maria D. (author)
- Emory Univ, Sch Med, Dept Med Cardiol, Atlanta, GA 30322 USA.
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- Naib, Hussain (author)
- Emory Univ, Sch Med, Dept Med Cardiol, Atlanta, GA 30322 USA.
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- Pejler, Gunnar (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Swedish Univ Agr Sci, Dept Anat Physiol & Biochem, Uppsala, Sweden.,Institutionen för anatomi, fysiologi och biokemi,Department of Anatomy, Physiology and Biochemistry (AFB),Uppsala University
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- Åbrink, Magnus (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Inst för biomedicin och veterinär folkhälsovetenskap,Department of Biomedical Science and Veterinary Public Health,Swedish Univ Agr Sci, Dept Biomed Sci & Vet Publ Hlth, Uppsala, Sweden.
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- Graham, Robert M. (author)
- Victor Chang Cardiac Res Inst, Sydney, NSW 2010, Australia.
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- Lefer, David J. (author)
- Emory Univ, Sch Med, Dept Surg, Carlyle Fraser Heart Ctr, Atlanta, GA 30322 USA.
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- Naqvi, Nawazish (author)
- Emory Univ, Sch Med, Dept Med Cardiol, Atlanta, GA 30322 USA.
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- Husain, Ahsan (author)
- Emory Univ, Sch Med, Dept Med Cardiol, Atlanta, GA 30322 USA.
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Emory Univ, Sch Med, Dept Med Cardiol, Atlanta, GA 30322 USA Emory Univ, Sch Med, Dept Surg, Carlyle Fraser Heart Ctr, Atlanta, GA 30322 USA. (creator_code:org_t)
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- 2016-06-06
- 2016
- English.
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In: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 113:25, s. 6949-6954
- Related links:
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https://www.pnas.org...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Heart disease is a leading cause of death in adults. Here, we show that a few days after coronary artery ligation and reperfusion, the ischemia-injured heart elaborates the cardioprotective polypeptide, insulin-like growth factor-1 (IGF-1), which activates IGF-1 receptor prosurvival signaling and improves cardiac left ventricular systolic function. However, this signaling is antagonized by the chymase, mouse mast cell protease 4 (MMCP-4), which degrades IGF-1. We found that deletion of the gene encoding MMCP-4 (Mcpt4), markedly reduced late, but not early, infarct size by suppressing IGF-1 degradation and, consequently, diminished cardiac dysfunction and adverse structural remodeling. Our findings represent the first demonstration to our knowledge of tissue IGF-1 regulation through proteolytic degradation and suggest that chymase inhibition may be a viable therapeutic approach to enhance late cardioprotection in post-ischemic heart disease.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- insulin-like growth factor-1
- chymase
- mouse mast cell protease 4
- ischemia-reperfusion injury
- cardioprotection
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Tejada, Thor
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Tan, Lin
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Torres, Rebecca ...
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Calvert, John W.
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Lambert, Jonatha ...
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Zaidi, Madiha
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show more...
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Husain, Murtaza
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Berce, Maria D.
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Naib, Hussain
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Pejler, Gunnar
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Åbrink, Magnus
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Graham, Robert M ...
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Lefer, David J.
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Naqvi, Nawazish
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Husain, Ahsan
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show less...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
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Proceedings of t ...
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Uppsala University
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Swedish University of Agricultural Sciences