Sökning: onr:"swepub:oai:DiVA.org:uu-307916" > Potentially modifia...
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000 | 05020naa a2200697 4500 | |
001 | oai:DiVA.org:uu-307916 | |
003 | SwePub | |
008 | 161122s2016 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3079162 URI |
024 | 7 | a https://doi.org/10.1007/s00134-016-4571-52 DOI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Laffey, John G4 aut |
245 | 1 0 | a Potentially modifiable factors contributing to outcome from acute respiratory distress syndrome :b the LUNG SAFE study |
264 | c 2016-10-18 | |
264 | 1 | b Springer,c 2016 |
338 | a print2 rdacarrier | |
500 | a A Correction to this article was published on 14 November 2017. Corrected and republished: Intensive Care Med (2016) 42:1865–1876 DOI 10.1007/s00134-016-4571-5A correction to this article is available online at https://doi.org/10.1007/s00134-017-4981-z. Intensive Care Med 44, 157–165 (2018). | |
520 | a Purpose: To improve the outcome of the acute respiratory distress syndrome (ARDS), one needs to identify potentially modifiable factors associated with mortality.Methods: The large observational study to understand the global impact of severe acute respiratory failure (LUNG SAFE) was an international, multicenter, prospective cohort study of patients with severe respiratory failure, conducted in the winter of 2014 in a convenience sample of 459 ICUs from 50 countries across five continents. A pre-specified secondary aim was to examine the factors associated with outcome. Analyses were restricted to patients (93.1 %) fulfilling ARDS criteria on day 1-2 who received invasive mechanical ventilation.Result: 2377 patients were included in the analysis. Potentially modifiable factors associated with increased hospital mortality in multivariable analyses include lower PEEP, higher peak inspiratory, plateau, and driving pressures, and increased respiratory rate. The impact of tidal volume on outcome was unclear. Having fewer ICU beds was also associated with higher hospital mortality. Non-modifiable factors associated with worsened outcome from ARDS included older age, active neoplasm, hematologic neoplasm, and chronic liver failure. Severity of illness indices including lower pH, lower PaO2/FiO2 ratio, and higher non-pulmonary SOFA score were associated with poorer outcome. Of the 578 (24.3 %) patients with a limitation of life-sustaining therapies or measures decision, 498 (86.0 %) died in hospital. Factors associated with increased likelihood of limitation of life-sustaining therapies or measures decision included older age, immunosuppression, neoplasia, lower pH and increased non-pulmonary SOFA scores.Conclusions: Higher PEEP, lower peak, plateau, and driving pressures, and lower respiratory rate are associated with improved survival from ARDS. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Anestesi och intensivvård0 (SwePub)302012 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Anesthesiology and Intensive Care0 (SwePub)302012 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Lungmedicin och allergi0 (SwePub)302192 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Respiratory Medicine and Allergy0 (SwePub)302192 hsv//eng |
653 | a Acute respiratory distress syndrome | |
653 | a Positive end-expiratory pressure | |
653 | a Patient outcome | |
653 | a Driving pressure | |
653 | a Peak inspiratory pressure | |
700 | 1 | a Bellani, Giacomo4 aut |
700 | 1 | a Pham, Tài4 aut |
700 | 1 | a Fan, Eddy4 aut |
700 | 1 | a Madotto, Fabiana4 aut |
700 | 1 | a Bajwa, Ednan K4 aut |
700 | 1 | a Brochard, Laurent4 aut |
700 | 1 | a Clarkson, Kevin4 aut |
700 | 1 | a Esteban, Andres4 aut |
700 | 1 | a Gattinoni, Luciano4 aut |
700 | 1 | a van Haren, Frank4 aut |
700 | 1 | a Heunks, Leo M4 aut |
700 | 1 | a Kurahashi, Kiyoyasu4 aut |
700 | 1 | a Laake, Jon Henrik4 aut |
700 | 1 | a Larsson, Andersu Uppsala universitet,Hedenstiernalaboratoriet4 aut0 (Swepub:uu)andla606 |
700 | 1 | a McAuley, Daniel F4 aut |
700 | 1 | a McNamee, Lia4 aut |
700 | 1 | a Nin, Nicolas4 aut |
700 | 1 | a Qiu, Haibo4 aut |
700 | 1 | a Ranieri, Marco4 aut |
700 | 1 | a Rubenfeld, Gordon D4 aut |
700 | 1 | a Thompson, B Taylor4 aut |
700 | 1 | a Wrigge, Hermann4 aut |
700 | 1 | a Slutsky, Arthur S4 aut |
700 | 1 | a Pesenti, Antonio4 aut |
710 | 2 | a Uppsala universitetb Hedenstiernalaboratoriet4 org |
773 | 0 | t Intensive Care Medicined : Springerg 42:12, s. 1865-1876q 42:12<1865-1876x 0342-4642x 1432-1238 |
856 | 4 | u https://link.springer.com/article/10.1007/s00134-016-4571-5y To The Article |
856 | 4 | u https://link.springer.com/content/pdf/10.1007/s00134-016-4571-5.pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-307916 |
856 | 4 8 | u https://doi.org/10.1007/s00134-016-4571-5 |
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