Maintenance versus Induction Therapy Choice on Outcomes after Autologous Transplantation for Multiple Myeloma

Bortezomib (V), lenalidomide (R), cyclophosphamide (C), and dexamethasone (D) are components of the most commonly used modern doublet (RD, VD) or triplet (VRD, CVD) initial induction regimens before autologous hematopoietic cell transplantation (AHCT) for multiple myeloma (MM) in the United States. In this study we evaluated 693 patients receiving "upfront" AHCT after initial induction therapy with modern doublet or triplet regimens using data reported to the Center for International Blood and Marrow Transplant Research from 2008 to 2013. Analysis was limited to those receiving a single AHCT after 1 line of induction therapy within 12 months from treatment initiation for MM. In multivariate analysis, progression-free survival (PFS) and overall survival were similar irrespective of induction regimen. However, high-risk cytogenetics and nonreceipt of post-transplant maintenance/consolidation therapy were associated with higher risk of relapse. Patients receiving post-transplant therapy had significantly improved 3-year PFS versus no post-transplant therapy (55% versus 39%, P = .0001). This benefit was most evident in patients not achieving at least a complete response post-AHCT (P = .005). In patients receiving upfront AHCT, the choice of induction regimen (doublet or triplet therapies) appears to be of lower impact than use of post-transplant therapy.

D'Souza, Anita (author)
Kassim, Adetola A (author)
Costa, Luciano J (author)
Innis-Shelton, Racquel D (author)
Zhang, Mei-Jie (author)
Huang, Jiaxing (author)
Abidi, Muneer (author)
Aiello, Jack (author)
Akpek, Gorgun (author)
Bashey, Asad (author)
Bashir, Qaiser (author)
Cerny, Jan (author)
Comenzo, Raymond (author)
Diaz, Miguel Angel (author)
Freytes, César (author)
Gale, Robert Peter (author)
Ganguly, Siddhartha (author)
Hamadani, Mehdi (author)
Hashmi, Shahrukh (author)
Holmberg, Leona (author)
Hossain, Nasheed (author)
Kamble, Rammurti T (author)
Kharfan-Dabaja, Mohamed (author)
Kindwall-Keller, Tamila (author)
Kyle, Robert (author)
Kumar, Shaji (author)
Lazarus, Hillard (author)
Lee, Cindy (author)
Maiolino, Angelo (author)
Marks, David I (author)
Meehan, Kenneth (author)
Mikhael, Joe (author)
Nath, Rajneesh (author)
Nishihori, Taiga (author)
Olsson, Richard F.Karolinska Institutet,Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD)(Swepub:uu)riols677 (author)
Ramanathan, Muthalagu (author)
Saad, Ayman (author)
Seo, Sachiko (author)
Usmani, Saad (author)
Vesole, David (author)
Vij, Ravi (author)
Vogl, Dan (author)
Wirk, Baldeep M (author)
Yared, Jean (author)
Krishnan, Amrita (author)
Mark, Tomer (author)
Nieto, Yago (author)
Hari, Parameswaran (author)
Uppsala universitetCentrum för klinisk forskning i Sörmland (CKFD) (creator_code:org_t)

In:Biology of blood and marrow transplantation: Elsevier BV23:2, s. 269-2771083-87911523-6536

By the author/editor: Cornell, Robert ...; D'Souza, Anita; Kassim, Adetola ...; Costa, Luciano J; Innis-Shelton, R ...; Zhang, Mei-Jie; show more...; Huang, Jiaxing; Abidi, Muneer; Aiello, Jack; Akpek, Gorgun; Bashey, Asad; Bashir, Qaiser; Cerny, Jan; Comenzo, Raymond; Diaz, Miguel Ang ...; Freytes, César; Gale, Robert Pet ...; Ganguly, Siddhar ...; Hamadani, Mehdi; Hashmi, Shahrukh; Holmberg, Leona; Hossain, Nasheed; Kamble, Rammurti ...; Kharfan-Dabaja, ...; Kindwall-Keller, ...; Kyle, Robert; Kumar, Shaji; Lazarus, Hillard; Lee, Cindy; Maiolino, Angelo; Marks, David I; Meehan, Kenneth; Mikhael, Joe; Nath, Rajneesh; Nishihori, Taiga; Olsson, Richard ...; Ramanathan, Muth ...; Saad, Ayman; Seo, Sachiko; Usmani, Saad; Vesole, David; Vij, Ravi; Vogl, Dan; Wirk, Baldeep M; Yared, Jean; Krishnan, Amrita; Mark, Tomer; Nieto, Yago; Hari, Parameswar ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Hematology

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.