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Are There Folding P...
Are There Folding Pathways in the Functional Stages of Intrinsically Disordered Proteins?
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- Ilieva, N. (författare)
- Inst Informat & Commun Technol BAS, Sofia, Bulgaria.
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- Liu, J. (författare)
- Beijing Inst Technol, Sch Phys, Beijing, Peoples R China.
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- Marinova, R. (författare)
- Sofia Univ St Kliment Ohridski, Fac Phys, Sofia, Bulgaria.
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- Petkov, P. (författare)
- Sofia Univ St Kliment Ohridski, Fac Phys, Sofia, Bulgaria.
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- Litov, L. (författare)
- Sofia Univ St Kliment Ohridski, Fac Phys, Sofia, Bulgaria.
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- He, J. (författare)
- Beijing Inst Technol, Sch Phys, Beijing, Peoples R China.
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- Niemi, Antti J. (författare)
- Uppsala universitet,Teoretisk fysik,Univ Tours, LMPT CNRS, Tours, France.
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visa färre...
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Inst Informat & Commun Technol BAS, Sofia, Bulgaria Beijing Inst Technol, Sch Phys, Beijing, Peoples R China. (creator_code:org_t)
- 2016
- 2016
- Engelska.
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Ingår i: Application Of Mathematics In Technical And Natural Sciences (AMITANS'16). - 9780735414310
- Relaterad länk:
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https://urn.kb.se/re...
Abstract
Ämnesord
Stäng
- We proceed from the description of protein folding by means of molecular dynamics (MD) simulations with all-atom force fields, with folding pathways interpreted in terms of soliton structures, to identify possible systematic dynamical patterns of self-organisation that govern protein folding process. We perform in silico investigations of the conformational transformations of three different proteins MYC protein (an alpha-helical protein), amylin and indolicidin (IDPs with different length and binding dynamics). We discuss the emergence of soliton-mediated secondary motifs, in the case of IDPs in the context of their functional activity. We hypothesize that soliton-like quasi-ordered conformations appear as an important intermediate stage in this process.
Ämnesord
- NATURVETENSKAP -- Fysik (hsv//swe)
- NATURAL SCIENCES -- Physical Sciences (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- kon (ämneskategori)
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