Search: onr:"swepub:oai:DiVA.org:uu-320291" >
DNA methylation pro...
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Bergmann, Anke K.Christian Albrechts Univ Kiel, Univ Hosp Schleswig Holstein, Inst Human Genet, Campus Kiel,Schwanenweg 24, Kiel, Germany.;Christian Albrechts Univ Kiel, Univ Hosp Schleswig Holstein, Dept Pediat, Campus Kiel, Kiel, Germany.
(author)
DNA methylation profiling of pediatric B-cell lymphoblastic leukemia with KMT2A rearrangement identifies hypomethylation at enhancer sites
- Article/chapterEnglish2017
Publisher, publication year, extent ...
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2016-10-27
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Wiley,2017
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-320291
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-320291URI
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https://doi.org/10.1002/pbc.26251DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Deregulation of the epigenome is an important pathogenetic mechanism in acute lymphoblastic leukemia (ALL) with lysine (K)-specific methyltransferase 2A rearrangement (KMT2Ar). We performed array-based DNA methylation profiling of KMT2Ar ALL cells from 26 children in comparison to normal B-cell precursors. Significant changes in DNA methylation in KMT2Ar ALL were identified in 2,545 CpG loci, influenced by age and the translocation partners AFF1 and MLLT1. In KMT2Ar ALL, DNA methylation loss was enriched at enhancers and for certain transcription factor binding sites such as BCL11A, EBF, and MEF2A. In summary, DNA methylation changes in KMT2Ar ALL target enhancers, genes involved in leukemogenesis and normal hematopoiesis, as well as transcription factor networks.
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Castellano, GiancarloUniv Barcelona, Inst Biomed August Pi Sunyer IDIBAPS, Dept Analomia Palol & Microbiol, Dept Farmacol & Microbiol, Barcelona, Spain.
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Alten, JuliaChristian Albrechts Univ Kiel, Univ Hosp Schleswig Holstein, Dept Pediat, Campus Kiel, Kiel, Germany.
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Ammerpohl, OleChristian Albrechts Univ Kiel, Univ Hosp Schleswig Holstein, Inst Human Genet, Campus Kiel,Schwanenweg 24, Kiel, Germany.
(author)
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Kolarova, JuliaChristian Albrechts Univ Kiel, Univ Hosp Schleswig Holstein, Inst Human Genet, Campus Kiel,Schwanenweg 24, Kiel, Germany.;Univ Ulm, Univ Med Ctr Ulm, Inst Human Genet, Ulm, Germany.
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Nordlund, JessicaUppsala universitet,Molekylär medicin,Science for Life Laboratory, SciLifeLab(Swepub:uu)jesno775
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Martin-Subero, Jose IgnacioUniv Barcelona, Inst Biomed August Pi Sunyer IDIBAPS, Dept Analomia Palol & Microbiol, Dept Farmacol & Microbiol, Barcelona, Spain.
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Schrappe, MartinChristian Albrechts Univ Kiel, Univ Hosp Schleswig Holstein, Dept Pediat, Campus Kiel, Kiel, Germany.
(author)
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Siebert, ReinerChristian Albrechts Univ Kiel, Univ Hosp Schleswig Holstein, Inst Human Genet, Campus Kiel,Schwanenweg 24, Kiel, Germany.;Univ Ulm, Univ Med Ctr Ulm, Inst Human Genet, Ulm, Germany.
(author)
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Christian Albrechts Univ Kiel, Univ Hosp Schleswig Holstein, Inst Human Genet, Campus Kiel,Schwanenweg 24, Kiel, Germany.;Christian Albrechts Univ Kiel, Univ Hosp Schleswig Holstein, Dept Pediat, Campus Kiel, Kiel, Germany.Univ Barcelona, Inst Biomed August Pi Sunyer IDIBAPS, Dept Analomia Palol & Microbiol, Dept Farmacol & Microbiol, Barcelona, Spain.
(creator_code:org_t)
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In:Pediatric Blood & Cancer: Wiley64:31545-50091545-5017
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