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Covariation in leve...
Covariation in levels of nucleotide diversity in homologous regions of the avian genome long after completion of lineage sorting
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- Dutoit, Ludovic (author)
- Uppsala universitet,Evolutionsbiologi
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- Vijay, Nagarjun (author)
- Uppsala universitet,Evolutionsbiologi,Univ Michigan, Dept Ecol & Evolutionary Biol, Lab Mol & Genom Evolut, Ann Arbor, MI USA.
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- Mugal, Carina F. (author)
- Uppsala universitet,Evolutionsbiologi
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- Bossu, Christen M. (author)
- Uppsala universitet,Evolutionsbiologi,Stockholm Univ, Dept Zool, S-10691 Stockholm, Sweden
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- Burri, Reto (author)
- Uppsala universitet,Evolutionsbiologi,Friedrich Schiller Univ, Inst Ecol, Dept Ecol, Dornburger Str 159 07743 Jena, Jena, Germany
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- Wolf, Jochen (author)
- Uppsala universitet,Evolutionsbiologi,Ludwig Maximilians Univ Munchen, Fac Biol 2, Div Evolutionary Biol, Grosshaderner Str 2, D-82152 Martinsried, Germany.
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- Ellegren, Hans (author)
- Uppsala universitet,Evolutionsbiologi
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(creator_code:org_t)
- 2017-02-22
- 2017
- English.
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In: Proceedings of the Royal Society of London. Biological Sciences. - : ROYAL SOC. - 0962-8452 .- 1471-2954. ; 284:1849
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https://royalsociety...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Closely related species may show similar levels of genetic diversity in homologous regions of the genome owing to shared ancestral variation still segregating in the extant species. However, after completion of lineage sorting, such covariation is not necessarily expected. On the other hand, if the processes that govern genetic diversity are conserved, diversity may potentially covary even among distantly related species. We mapped regions of conserved synteny between the genomes of two divergent bird speciescollared flycatcher and hooded crow-and identified more than 600 Mb of homologous regions (66% of the genome). From analyses of whole-genome resequencing data in large population samples of both species we found nucleotide diversity in 200 kb windows to be well correlated (Spearman's rho = 0.407). The correlation remained highly similar after excluding coding sequences. To explain this covariation, we suggest that a stable avian karyotype and a conserved landscape of recombination rate variation render the diversity-reducing effects of linked selection similar in divergent bird lineages. Principal component regression analysis of several potential explanatory variables driving heterogeneity in flycatcher diversity levels revealed the strongest effects from recombination rate variation and density of coding sequence targets for selection, consistent with linked selection. It is also possible that a stable karyotype is associated with a conserved genomic mutation environment contributing to covariation in diversity levels between lineages. Our observations imply that genetic diversity is to some extent predictable.
Subject headings
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Keyword
- nucleotide diversity
- linked selection
- recombination rate
- birds
Publication and Content Type
- ref (subject category)
- art (subject category)
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