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Short-term dabigatr...
Short-term dabigatran interruption before cardiac rhythm device implantation : multi-centre experience from the RE-LY trial
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- Essebag, Vidal (author)
- McGill Univ, Hlth Ctr, 1650 Cedar Ave,Room E5-200, Montreal, PQ H3G 1A4, Canada.;Hop Sacre Coeur, Montreal, PQ, Canada.
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- Proietti, Riccardo (author)
- Swansea Univ, Cardiol Dept, Morriston Hosp, Swansea SA6 6NL, W Glam, Wales.;Luigi Sacco Hosp, Cardiol Dept, Milan, Italy.
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- Birnie, David H. (author)
- Univ Ottawa Heart Inst, Ottawa, ON, Canada.
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- Wang, Jia (author)
- McMaster Univ, Populat Hlth Res Inst, Hamilton, ON, Canada.
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- Douketis, James (author)
- McMaster Univ, Dept Med, St Josephs Healthcare, Hamilton, ON, Canada.
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- Coutu, Benoit (author)
- Ctr Hosp Univ Montre, Montreal, PQ, Canada.
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- Parkash, Ratika (author)
- Queen Elizabeth 2 Hlth Sci Ctr, Halifax, NS, Canada.
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- Lip, Gregory Y. H. (author)
- Univ Birmingham, Inst Cardiovasc Sci, City Hosp, Birmingham, W Midlands, England.
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- Hohnloser, Stefan H. (author)
- Klinikum Johann Wolfgang Goethe Univ, Frankfurt, Germany.
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- Moriarty, Andrew (author)
- Craigavon Area Hosp, Portadown, Arm, North Ireland.
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- Oldgren, Jonas, 1964- (author)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi
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- Connolly, Stuart J. (author)
- McMaster Univ, Populat Hlth Res Inst, Hamilton, ON, Canada.
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- Ezekowitz, Michael (author)
- Thomas Jefferson Med Coll & Heart Ctr, Wynnewood, PA USA.
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- Healey, Jeff S. (author)
- McMaster Univ, Populat Hlth Res Inst, Hamilton, ON, Canada.
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McGill Univ, Hlth Ctr, 1650 Cedar Ave,Room E5-200, Montreal, PQ H3G 1A4, Canada;Hop Sacre Coeur, Montreal, PQ, Canada. Swansea Univ, Cardiol Dept, Morriston Hosp, Swansea SA6 6NL, W Glam, Wales.;Luigi Sacco Hosp, Cardiol Dept, Milan, Italy. (creator_code:org_t)
- 2017-02-23
- 2017
- English.
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In: Europace. - : OXFORD UNIV PRESS. - 1099-5129 .- 1532-2092. ; 19:10, s. 1630-1636
- Related links:
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https://academic.oup...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Aims: Cardiac implantable electronic device (CIED) surgery is commonly performed in patients with atrial fibrillation (AF). The current analysis was undertaken to compare peri-operative anticoagulation management, bleeding, and thrombotic events in AF patients treated with dabigatran vs. warfarin.Methods and results: This study included 611 patients treated with dabigatran vs. warfarin who underwent CIED surgery during the RE-LY trial. Among 201 warfarin-treated patients, warfarin was interrupted a median of 144 (inter-quartile range, IQR: 120-216) h, and 37 (18.4%) patients underwent heparin bridging. In dabigatran-treated patients (216 on 110 mg bid and 194 on 150 mg bid), the duration of dabigatran interruption was a median of 96 (IQR: 61-158) h. Pocket hematomas occurred in 9 (2.20%) patients on dabigatran and 8 (3.98%) patients on warfarin (P = 0.218). The occurrence of pocket hematomas was lower with dabigatran compared with warfarin with heparin bridging (RD: -8.62%, 95% CI: -24.15 to - 0.51%, P = 0.034) but not when compared with warfarin with no bridging (P = 0.880). Ischemic stroke occurred in 2 (0.3%) patients; one in the warfarin group (without bridging) and one in the dabigatran 150 mg bid group (P = 0.735).Conclusion: In patients treated with dabigatran undergoing CIED surgery, interruption of dabigatran is associated with similar or lower incidence of pocket hematoma, when compared with warfarin interruption without or with heparin bridging, respectively. Whether uninterrupted dabigatran can reduce pocket hematoma or ischemic stroke remains to be evaluated.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Dabigatran
- Warfarin
- Hematoma
- Anticoagulation
- Device implantation
Publication and Content Type
- ref (subject category)
- art (subject category)
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Europace
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- By the author/editor
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Essebag, Vidal
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Proietti, Riccar ...
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Birnie, David H.
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Wang, Jia
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Douketis, James
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Coutu, Benoit
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Parkash, Ratika
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Lip, Gregory Y. ...
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Hohnloser, Stefa ...
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Moriarty, Andrew
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Oldgren, Jonas, ...
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Connolly, Stuart ...
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Ezekowitz, Micha ...
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Healey, Jeff S.
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
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Europace
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Uppsala University