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Structural and func...
Structural and functional aspects of the interaction partners of the small heat-shock protein in Synechocystis
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- Marklund, Erik G., Teknologie doktor, 1979- (author)
- Uppsala universitet,Biokemi,University of Oxford, Oxford, UK
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- Zhang, Yichen (author)
- University of Massachusetts, Amherst, USA; Alorica Inc, Irvine, CA USA
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- Basha, Eman (author)
- University of Massachusetts, Amherst, USA; Univ Arizona, Dept Mol & Cellular Biol, Tucson, AZ USA
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- Benesch, Justin L P (author)
- University of Oxford, Oxford, UK
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- Vierling, Elizabeth (author)
- University of Massachusetts, Amherst, USA
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(creator_code:org_t)
- 2018-02-23
- 2018
- English.
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In: Cell stress & chaperones (Print). - : Springer Science and Business Media LLC. - 1355-8145 .- 1466-1268. ; 23:4, s. 723-732
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Abstract
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- The canonical function of small heat-shock proteins (sHSPs) is to interact with proteins destabilized under conditions of cellular stress. While the breadth of interactions made by many sHSPs is well-known, there is currently little knowledge about what structural features of the interactors form the basis for their recognition. Here, we have identified 83 in vivo interactors of the sole sHSP in the cyanobacterium Synechocystis sp. PCC 6803, HSP16.6, reflective of stable associations with soluble proteins made under heat-shock conditions. By performing bioinformatic analyses on these interactors, we identify primary and secondary structural elements that are enriched relative to expectations from the cyanobacterial genome. In addition, by examining the Synechocystis interactors and comparing them with those identified to bind sHSPs in other prokaryotes, we show that sHSPs associate with specific proteins and biological processes. Our data are therefore consistent with a picture of sHSPs being broadly specific molecular chaperones that act to protect multiple cellular pathways.
Subject headings
- NATURVETENSKAP -- Biologi -- Bioinformatik och systembiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Bioinformatics and Systems Biology (hsv//eng)
Keyword
- Bioinformatics
- Cyanobacteria
- Molecular chaperone
- Small heat-shock protein
- α-Crystallins
- Bioinformatics
- Bioinformatik
Publication and Content Type
- ref (subject category)
- art (subject category)
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