Sökning: onr:"swepub:oai:DiVA.org:uu-344283" >
Dietary Intake of P...
-
Lourdudoss, Cecilia
(författare)
Dietary Intake of Polyunsaturated Fatty Acids and Pain in Spite of Inflammatory Control Among Methotrexate-Treated Early Rheumatoid Arthritis Patients.
- Artikel/kapitelEngelska2018
Förlag, utgivningsår, omfång ...
-
2018-01-29
-
Wiley,2018
-
printrdacarrier
Nummerbeteckningar
-
LIBRIS-ID:oai:DiVA.org:uu-344283
-
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-344283URI
-
https://doi.org/10.1002/acr.23245DOI
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:137507373URI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
OBJECTIVE: To investigate potential associations between dietary intake of polyunsaturated fatty acids (FAs) and pain patterns in early rheumatoid arthritis (RA) patients after 3 months of methotrexate (MTX) treatment.METHODS: We included 591 early RA patients with MTX monotherapy from a population-based prospective case-control study, the Epidemiological Investigation of Rheumatoid Arthritis. Dietary data on polyunsaturated FAs (food frequency questionnaires) were linked with data on unacceptable pain (visual analog scale [VAS] >40 mm), noninflammatory/refractory pain (VAS >40 mm and C-reactive protein [CRP] level <10 mg/liter), and inflammatory pain (VAS >40 mm and CRP level >10 mg/liter) after 3 months. Statistical analysis included logistic regression.RESULTS: After 3 months of MTX treatment, 125 patients (21.2%) had unacceptable pain, of which 92 patients had refractory pain, and 33 patients had inflammatory pain. Omega-3 FA intake was inversely associated with unacceptable pain and refractory pain (odds ratio [OR] 0.57 [95% confidence interval (95% CI) 0.35-0.95] and OR 0.47 [95% CI 0.26-0.84], respectively). The omega-6:omega-3 FA ratio, but not omega-6 FA alone, was directly associated with unacceptable pain and refractory pain (OR 1.70 [95% CI 1.03-2.82] and OR 2.33 [95% CI 1.28-4.24], respectively). Furthermore, polyunsaturated FAs were not associated with either inflammatory pain or CRP level and erythrocyte sedimentation rate at followup. Omega-3 FA supplementation was not associated with any pain patterns.CONCLUSION: Omega-3 FA was inversely associated with, and the omega-6:omega-3 FA ratio was directly associated with, unacceptable and refractory pain, but not with inflammatory pain or systemic inflammation. The inverse association between omega-3 FA and refractory pain may have a role in pain suppression in RA.
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Di Giuseppe, DanielaKarolinska Institutet
(författare)
-
Wolk, AlicjaKarolinska Institutet,Karolinska Institutet, Stockholm, Sweden(Swepub:uu)alwol516
(författare)
-
Westerlind, HelgaKarolinska Institutet
(författare)
-
Klareskog, LarsKarolinska Institutet
(författare)
-
Alfredsson, LarsKarolinska Institutet
(författare)
-
van Vollenhoven, Ronald FKarolinska Institutet
(författare)
-
Lampa, JonKarolinska Institutet
(författare)
-
Karolinska InstitutetKarolinska Institutet, Stockholm, Sweden
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Arthritis care & research: Wiley70:2, s. 205-2122151-464X2151-4658
Internetlänk
Hitta via bibliotek
Till lärosätets databas