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Efficacy and safety...
Efficacy and safety of dabigatran compared with warfarin in patients with atrial fibrillation in relation to renal function over time-A RE-LY trial analysis
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- Hijazi, Ziad (författare)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi
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- Hohnloser, Stefan H. (författare)
- Goethe Univ Frankfurt, Dept Cardiol, Frankfurt, Germany
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- Oldgren, Jonas, 1964- (författare)
- Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)
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- Andersson, Ulrika (författare)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)
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- Connolly, Stuart J. (författare)
- Populat Hlth Res Inst, Hamilton, ON, Canada
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- Eikelboom, John W. (författare)
- Populat Hlth Res Inst, Hamilton, ON, Canada
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- Ezekowitz, Michael D. (författare)
- Thomas Jefferson Med Coll, Wynnewood, PA USA;Heart Ctr, Wynnewood, PA USA
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- Reilly, Paul A. (författare)
- Boehringer Ingelheim Pharmaceut, Ridgefield, CT USA
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- Yusuf, Salim (författare)
- Populat Hlth Res Inst, Hamilton, ON, Canada
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- Wallentin, Lars, 1943- (författare)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)
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(creator_code:org_t)
- MOSBY-ELSEVIER, 2018
- 2018
- Engelska.
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Ingår i: American Heart Journal. - : MOSBY-ELSEVIER. - 0002-8703 .- 1097-6744. ; 198, s. 169-177
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Renal function may decline over time, and the efficacy and safety of dabigatran in atrial fibrillation (AF) in relation to renal function changes are unknown.& para;& para;Methods: The RE-LY trial randomized 18,113 patients with AF to 2 doses of dabigatran or warfarin for stroke prevention. Serial creatinine measurements were available in 16,988 patients. The relations between treatment, outcomes, and renal function (Cockcroft-Gault) were investigated using Cox-regression (1) with renal function as a time-dependent covariate and (2) according to worsening renal function (WRF) during follow-up, predefined as a decline in estimated glomerular filtration rate >20% from baseline.& para;& para;Results: During a median follow-up of 1.8 years, 4,106 (24.2%) participants were observed to have WRF, and 12,882 (75.8%) had stable renal function. The risks of all-cause mortality and major bleeding were higher in patients with WRF versus those with stable renal function (hazard ratio [95% CI]: 2.17 [1.81-2.59] and 1.43 [1.19-1.71]. respectively; both P < .0005). The efficacy and safety of dabigatran versus warfarin were similar irrespective of renal function changes over time (interaction P values >= .13 in both models). Dabigatran 110 mg showed a greater relative risk reduction of major bleeding in patients with normal renal function (estimated glomerular filtration rate >80 mL/min) during follow-up (interaction P= .026).& para;& para;Conclusions: In AF, WRF was associated with a higher risk of death and major bleeding. The efficacy and safety profile of dabigatran compared with warfarin was similar irrespective of renal function changes over time. Dabigatran 110 mg showed a greater relative risk reduction of major bleeding in patients with normal renal function during follow-up.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
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Hijazi, Ziad
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Hohnloser, Stefa ...
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Oldgren, Jonas, ...
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Andersson, Ulrik ...
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Connolly, Stuart ...
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Eikelboom, John ...
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visa fler...
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Ezekowitz, Micha ...
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Reilly, Paul A.
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Yusuf, Salim
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Wallentin, Lars, ...
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
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American Heart J ...
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Uppsala universitet